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Electrochemical Screening and Evaluation of Lamiaceae Plant Species from South Africa with Potential Tyrosinase Activity

Chemistry Department, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa
Department of Chemistry, Cape Peninsula University of Technology, Private Bag X6, Bellville 7535, South Africa
Author to whom correspondence should be addressed.
Sensors 2019, 19(5), 1035;
Received: 5 December 2018 / Revised: 11 January 2019 / Accepted: 11 January 2019 / Published: 28 February 2019
(This article belongs to the Special Issue Enzyme-Based Biosensors for Biomedical Analysis)
PDF [3038 KB, uploaded 28 February 2019]


South Africa is a country with a wide variety of plants that may contain excellent anti-tyrosinase inhibitors. With wide applications in cosmetics, pharmaceuticals and food products, tyrosinase inhibitors have received very special attention in the recent past as a way of preventing the overproduction of melanin in epidermal layers which often over time brings detrimental effects on human skin. In this present study, a fast screening method using a cyclic voltammetry technique was applied in the evaluation of methanolic extracts of twenty-five species of plants from the Lamiaceae family for anti-tyrosinase activity. Among these plants, those that showed a fast current inhibition rate at a minimum concentration when compared to a kojic acid standard were classified as having the greatest anti-tyrosinase activity. These include Salvia chamelaeagnea, S. dolomitica, Plectranthus ecklonii, P. namaensis, and P. zuluensis. The results presented herein focused in particular on providng firsthand information for further extensive research and exploration of natural product materials with anti-tyrosinase activity from South African flora for use in cosmetics, skin care and medicinal treatments. View Full-Text
Keywords: screening; Lamiaceae; extracts; tyrosinase inhibitors; cyclic voltammetry; cosmetics screening; Lamiaceae; extracts; tyrosinase inhibitors; cyclic voltammetry; cosmetics

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Etsassala, N.G.; Waryo, T.; Popoola, O.K.; Adeloye, A.O.; Iwuoha, E.I.; Hussein, A.A. Electrochemical Screening and Evaluation of Lamiaceae Plant Species from South Africa with Potential Tyrosinase Activity. Sensors 2019, 19, 1035.

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