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Ferrocenyl-bis-(1-(4-benzyl-5-morpholinooxazol-2-yl)-N-(4-(trifluoromethyl)benzyl)methanamine)

Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, Av. Ferrocarril San Rafael Atlixco 186, Col. Leyes de Reforma 1A Sección, Iztapalapa, Ciudad de Mexico C.P. 09310, Mexico
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Academic Editor: Fawaz Aldabbagh
Molbank 2022, 2022(3), M1444; https://doi.org/10.3390/M1444
Received: 3 September 2022 / Revised: 7 September 2022 / Accepted: 8 September 2022 / Published: 13 September 2022
(This article belongs to the Collection Heterocycle Reactions)
The new bis-heterocyclic compound ferrocenyl-bis-(1-(4-benzyl-5-morpholinooxazol-2-yl)-N-(4-(trifluoromethyl)benzyl)methanamine) (1) was synthesized in 73% overall yield in 1.5 hours via a pseudo-repetitive Ugi-Zhu five-component reaction, starting from 1,1′-ferrocenedicarboxaldehyde, 4-(trifluoromethyl)benzylamine, and 2-isocyano-1-morpholino-3-phenylpropan-1-one, in 1:2.1:2.2 proportions, respectively, using scandium(III) triflate as a Lewis-acid catalyst, microwaves as a heat source, and toluene as a solvent. The synthesized compound was characterized by 1D (1H, 13C, and 19F) and 2D (COSY, HSQC, and HMBC) NMR, HRMS, and FT-IR. View Full-Text
Keywords: pseudo-repetitive multicomponent reactions; Ugi-Zhu reaction; MW-assisted reactions; ferrocene; 1,3-Oxazole; hybrid compounds pseudo-repetitive multicomponent reactions; Ugi-Zhu reaction; MW-assisted reactions; ferrocene; 1,3-Oxazole; hybrid compounds
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MDPI and ACS Style

Blanco-Carapia, R.E.; Aguilar-Rangel, E.A.; Islas-Jácome, A.; González-Zamora, E. Ferrocenyl-bis-(1-(4-benzyl-5-morpholinooxazol-2-yl)-N-(4-(trifluoromethyl)benzyl)methanamine). Molbank 2022, 2022, M1444. https://doi.org/10.3390/M1444

AMA Style

Blanco-Carapia RE, Aguilar-Rangel EA, Islas-Jácome A, González-Zamora E. Ferrocenyl-bis-(1-(4-benzyl-5-morpholinooxazol-2-yl)-N-(4-(trifluoromethyl)benzyl)methanamine). Molbank. 2022; 2022(3):M1444. https://doi.org/10.3390/M1444

Chicago/Turabian Style

Blanco-Carapia, Roberto E., Enrique A. Aguilar-Rangel, Alejandro Islas-Jácome, and Eduardo González-Zamora. 2022. "Ferrocenyl-bis-(1-(4-benzyl-5-morpholinooxazol-2-yl)-N-(4-(trifluoromethyl)benzyl)methanamine)" Molbank 2022, no. 3: M1444. https://doi.org/10.3390/M1444

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