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Styryl Hemicyanine Dye (E)-3-Methyl-2-(4-thiomorpholinostyryl)benzo[d]thiazol-3-ium Iodide for Nucleic Acids and Cell Nucleoli Visualization

1
Faculty of Chemistry and Pharmacy, University of Sofia “St. Kliment Ohridski”, 1 J. Bourchier Ave., 1164 Sofia, Bulgaria
2
Department of Medical Chemistry and Biochemistry, Medical Faculty, Medical University-Sofia, 2 Zdrave Str., 1431 Sofia, Bulgaria
*
Author to whom correspondence should be addressed.
Academic Editor: Fawaz Aldabbagh
Molbank 2022, 2022(2), M1392; https://doi.org/10.3390/M1392
Received: 31 May 2022 / Revised: 15 June 2022 / Accepted: 15 June 2022 / Published: 20 June 2022
(This article belongs to the Collection Heterocycle Reactions)
(E)-3-Methyl-2-(4-thiomorpholinostyryl)benzo[d]thiazol-3-ium iodide 1 was prepared by a convenient and reliable reaction procedure. The slight molar excess of the starting benzaldehyde and the mixture of ethanol: ethyl acetate in the ratio 3:1 as a solvent afforded a pure reaction product. The photophysical properties of the dye in a TE buffer in the absence and presence of double-stranded DNA (dsDNA) were elucidated. The low intrinsic fluorescence of 1 in TE buffer is followed by an increase in the fluorescence after dsDNA binding. The dye is nontoxic for stem cells from apical papilla and the most concentrated fluorescence is detected in the cell nucleoli. View Full-Text
Keywords: monomethyne cyanine dyes; thiomorpholine; DNA; stem cells; apical papilla monomethyne cyanine dyes; thiomorpholine; DNA; stem cells; apical papilla
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MDPI and ACS Style

Vasilev, A.A.; Miteva, M.; Ishkitiev, N.; Dragneva, M.; Topalova, L.; Kandinska, M.I. Styryl Hemicyanine Dye (E)-3-Methyl-2-(4-thiomorpholinostyryl)benzo[d]thiazol-3-ium Iodide for Nucleic Acids and Cell Nucleoli Visualization. Molbank 2022, 2022, M1392. https://doi.org/10.3390/M1392

AMA Style

Vasilev AA, Miteva M, Ishkitiev N, Dragneva M, Topalova L, Kandinska MI. Styryl Hemicyanine Dye (E)-3-Methyl-2-(4-thiomorpholinostyryl)benzo[d]thiazol-3-ium Iodide for Nucleic Acids and Cell Nucleoli Visualization. Molbank. 2022; 2022(2):M1392. https://doi.org/10.3390/M1392

Chicago/Turabian Style

Vasilev, Aleksey A., Marina Miteva, Nikolay Ishkitiev, Maria Dragneva, Lora Topalova, and Meglena I. Kandinska. 2022. "Styryl Hemicyanine Dye (E)-3-Methyl-2-(4-thiomorpholinostyryl)benzo[d]thiazol-3-ium Iodide for Nucleic Acids and Cell Nucleoli Visualization" Molbank 2022, no. 2: M1392. https://doi.org/10.3390/M1392

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