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Reactions of Polychlorinated Pyrimidines with DABCO

Department of Life Sciences, School of Sciences, European University Cyprus, 6 Diogenis Str., Engomi, P. O. Box 22006, 1516 Nicosia, Cyprus
Department of Chemistry, University of Cyprus, P. O. Box 20537, 1678 Nicosia, Cyprus
Author to whom correspondence should be addressed.
Molbank 2019, 2019(4), M1084;
Received: 27 September 2019 / Revised: 11 October 2019 / Accepted: 12 October 2019 / Published: 14 October 2019
The reaction of 2,4,5,6-tetrachloropyrimidine (4) and 4,5,6-trichloropyrimidine-2-carbonitrile (1) with DABCO (1 equiv.), in MeCN, at ca. 20 °C gives 2,4,5-trichloro-6-[4-(2-chloroethyl)piperazin-1-yl]pyrimidine (5) and 4,5-dichloro-6-[4-(2-chloroethyl)piperazin-1-yl]pyrimidine-2-carbonitrile (6) in 42% and 52% yields, respectively. The new compounds were fully characterized. View Full-Text
Keywords: heterocycle; piperazine; pyrimidine; DABCO heterocycle; piperazine; pyrimidine; DABCO
MDPI and ACS Style

Kalogirou, A.S.; Koutentis, P.A. Reactions of Polychlorinated Pyrimidines with DABCO. Molbank 2019, 2019, M1084.

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