Molbank, Volume 2008, Issue 2

As part of a research programme targeting novel molecules derived from o-hydroxyaryl ketone hydrazones[1] we synthesised 7-hydroxy-8-acetylcoumarin phenylsulfonylhydrazone.[...]

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As part of a research programme targeting novel molecules derived from nitrogen derivatives of o-hydroxyaryl ketones [1] we synthesised 7-hydroxy-8-acetylcoumarin oxime and we subsequently oxidized it with lead tetraacetate (LTA) as well as with diac...

It is well known that both isoxazole ring as well as pyrazole ring possess various biological activities and they both show interesting antimicrobial activity [1,2,3].[...]

As part of a research programme targeting novel molecules derived from nitrogen derivatives of o-hydroxyaryl ketones [1] we synthesised 7-hydroxy-8-acetylcoumarin benzoylhydrazone.[...]

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Methyl (2E)-3-methoxyacrylate and excess methylhydrazine yield crude 1- methyl-2-pyrazolin-5-one which is reacted with cyclohexanone to obtain the title compound in 86% yield. Detailed spectroscopic data (1H NMR, 13C NMR, 15N NMR, and MS) are presented.

The conjugation of a drug with one or more lipoamino acids (LAAs; 2-aminoalkanoic acids; e.g. 3) can impart upon the drug steric protection from enzymatic degradation, increased lipophilicity, increased passive membrane diffusion and therefore may im...