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Volume 26
Issue 11
10.3390/ijms26115156
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Review
Peer-Review Record

Phase Separation in Chromatin Organization and Human Diseases

Int. J. Mol. Sci. 2025, 26(11), 5156; https://doi.org/10.3390/ijms26115156
by Ziwei Zhai 1,2,†, Fei Meng 1,†, Junqi Kuang 2,3,* and Duanqing Pei 2,3,*
Reviewer 1:
Michael Hausmann
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2025, 26(11), 5156; https://doi.org/10.3390/ijms26115156
Submission received: 28 April 2025 / Revised: 25 May 2025 / Accepted: 26 May 2025 / Published: 28 May 2025
(This article belongs to the Special Issue Recent Advances in Chromatin Structure and Dynamics)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

The review article "Phase Separation in Chromatin Organization and Human Diseases" by Ziwei Zhai et al. discusses recent findings on the mechanisms of chromatin organization mediated by phase separation focussing on the roles of phase-separated condensates in chromatin structural dysregulation in human diseases. The article is well written and summarizes a huge amount of relevant literature. Nevertheless I would also draw the attention on the following articles which may be included where appropriate (especially in the context of selforganization principles as driving forces):
DOI: 10.4415/ANN_24_01_11
doi.org/10.1371/journal.pone.0167912
doi.org/10.1371/journal.pbio.2000640
doi.org/10.3390/ijms21010240
doi: 10.3390/ijms21134581
doi.org/10.1016/j.ygeno.2021.11.027
doi.org/10.1016/j.plrev.2021.03.001
dx.doi.org/10.1016/j.physa.2016.12.016
In line 77: the 30 nm fiber is controversely discussed. It is not clear whether it really exist. Please mention.

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 2 Report

Comments and Suggestions for Authors

In this manuscript, Ziwei Zhai and colleagues discuss recent findings on the mechanisms of chromatin organization mediated by phase separation, with a focus on the roles of phase-separated condensates in chromatin structural dysregulation in human diseases. I have following comments:

1, For the Abstract, practical interest of this study should be provided.

2, For the Figure 1, abbreviations appeared in the figure like MED1,BRD4 should be explained in the legend.

3, Key genes regulating phase separation associated with chromatin organization and human diseases should be summarized in Tables.

4, A conclusion section should be included.

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

Comments and Suggestions for Authors

Authors have positively respond to my questions in the revision.

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