Influence of Surgical Procedures on C-Reactive Protein Levels in Severely Burned Patients: Preliminary Analysis on Implications for Early Sepsis Diagnosis
Abstract
1. Introduction
2. Results
2.1. Study Group Characteristics
2.2. CRP Levels in Fascial Necrectomy Group
2.3. CRP Levels After Tangential Necrectomy
2.4. CRP Level After Skin Graft Harvesting
3. Discussion
4. Materials and Methods
4.1. Study Population
4.2. Inclusion and Exclusion Criteria
- Ages between 18 and 75;
- Thermal injury;
- Second b- and third-degree burns, with an area of no less than 20% and no more than 50% of total body surface area (TBSA);
- Patients who underwent only one of the following surgical procedures during a single operation: (1) tangential necrectomy, (2) fascial necrectomy, or (3) split-thickness skin graft harvesting;
- The surgical procedure encompassed 5–20% of TBSA.
- Electric or chemical injury;
- Patients who underwent more than one of the listed above surgical procedures during a single operation;
- Surgical procedure performed on an area of less than 5% and greater than 20% TBSA;
- Diagnosis of a concomitant disease that significantly affected the immune response;
- Immune deficiency;
- Immunosuppressive treatment at the time of injury.
4.3. Study Design
- Group I: tangential necrectomy
- Group II: fascial necrectomy
- Group III: split-thickness skin harvesting for grafting
4.4. Material Collection and CRP Analysis
4.5. Ethical Statement
4.6. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Feature | N |
---|---|
Total patients included | 93 |
Age (years), mean ± SD | 47.6 ± 15.0 |
Age, median (range) | 50 (20–74) |
Gender distribution | 88% male, 12% female |
TBSA (%), mean ± SD | 33.1 ± 8.9 |
TBSA, median | 35% |
% II-degree burns, mean ± SD | 4.9 ± 6.6 |
% III-degree burns, mean ± SD | 22.6 ± 7.0 |
Inhalation injuries | 10 patients |
Chronic comorbidities | 6 patients |
Length of hospitalization (days), mean ± SD | 79.4 ± 52.1 |
Length of hospitalization, range | 19–292 |
Time | Control Group | Study Group 3 h Post Op | Study Group 9 h Post Op | |
---|---|---|---|---|
Parameter | ||||
Minimum | 59.57 | 57.17 | 55.48 | |
Maximum | 379.32 | 324.08 | 329.10 | |
Average | 187.42 | 181.97 | 183.59 | |
Median | 173.47 | 177.10 | 176.85 | |
Standard deviation | 77.39 | 71.21 | 72.99 | |
Comparison analysis | ||||
Comparison | p-value | Significance | ||
Control vs. 3 h | 0.44 | Not significant | ||
Control vs. 9 h | 0.59 | Not significant | ||
3 h vs. 9 h | 0.53 | Not significant |
Time | Control Group | Study Group 3 h Post Op | Study Group 9 h Post Op | |
---|---|---|---|---|
Parameter | ||||
Minimum | 41.21 | 36.97 | 36.63 | |
Maximum | 427.88 | 450.16 | 456.62 | |
Average | 173.16 | 173.54 | 188.23 | |
Median | 148.06 | 131.87 | 138.90 | |
Standard deviation | 108.49 | 111.23 | 115.86 | |
Comparison analysis | ||||
Comparison | p-value | Significance | ||
Control vs. 3 h | 0.35 | Not significant | ||
Control vs. 9 h | 0.19 | Not significant | ||
3 h vs. 9 h | 0.0027 | Significant |
Time | Control Group | Study Group 3 h Post Op | Study Group 9 h Post Op | |
---|---|---|---|---|
Parameter | ||||
Minimum | 4.13 | 4.54 | 4.98 | |
Maximum | 324.50 | 336.16 | 332.32 | |
Average | 115.62 | 110.20 | 113.91 | |
Median | 94.33 | 85.26 | 90.24 | |
Standard deviation | 91.01 | 87.00 | 89.2992 | |
Comparison analysis | ||||
Comparison | p-value | Significance | ||
Control vs. 3 h | 0.0165 | Significant | ||
Control vs. 9 h | 0.4 | Not significant | ||
3 h vs. 9 h | 0.12 | Not Significant |
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Makowska-Rezaie, M.B.; Jeleń, M.; Bartoszewicz, M.; Korzeniowski, T.; Klimeczek-Chrapusta, M.K.; Chrapusta, A.M. Influence of Surgical Procedures on C-Reactive Protein Levels in Severely Burned Patients: Preliminary Analysis on Implications for Early Sepsis Diagnosis. Int. J. Mol. Sci. 2025, 26, 5158. https://doi.org/10.3390/ijms26115158
Makowska-Rezaie MB, Jeleń M, Bartoszewicz M, Korzeniowski T, Klimeczek-Chrapusta MK, Chrapusta AM. Influence of Surgical Procedures on C-Reactive Protein Levels in Severely Burned Patients: Preliminary Analysis on Implications for Early Sepsis Diagnosis. International Journal of Molecular Sciences. 2025; 26(11):5158. https://doi.org/10.3390/ijms26115158
Chicago/Turabian StyleMakowska-Rezaie, Małgorzata Barbara, Michał Jeleń, Marzenna Bartoszewicz, Tomasz Korzeniowski, Maria Kamila Klimeczek-Chrapusta, and Anna Marta Chrapusta. 2025. "Influence of Surgical Procedures on C-Reactive Protein Levels in Severely Burned Patients: Preliminary Analysis on Implications for Early Sepsis Diagnosis" International Journal of Molecular Sciences 26, no. 11: 5158. https://doi.org/10.3390/ijms26115158
APA StyleMakowska-Rezaie, M. B., Jeleń, M., Bartoszewicz, M., Korzeniowski, T., Klimeczek-Chrapusta, M. K., & Chrapusta, A. M. (2025). Influence of Surgical Procedures on C-Reactive Protein Levels in Severely Burned Patients: Preliminary Analysis on Implications for Early Sepsis Diagnosis. International Journal of Molecular Sciences, 26(11), 5158. https://doi.org/10.3390/ijms26115158