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Article

Toxicogenomics of the Freshwater Oligochaete, Tubifex tubifex (Annelida, Clitellata), in Acute Water-Only Exposure to Arsenic

by
Iñigo Moreno-Ocio
1,†,
Mónica Aquilino
2,†,
Lola Llorente
2,
Maite Martínez-Madrid
3,
Pilar Rodríguez
1,
Leire Méndez-Fernández
3,* and
Rosario Planelló
2,*
1
Department of Zoology and Animal Cell Biology, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain
2
Molecular Entomology, Biomarkers and Environmental Stress Group, Faculty of Science, Universidad Nacional de Educación a Distancia (UNED), 28232 Las Rozas de Madrid, Spain
3
Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2024, 25(6), 3382; https://doi.org/10.3390/ijms25063382
Submission received: 28 January 2024 / Revised: 8 March 2024 / Accepted: 15 March 2024 / Published: 16 March 2024
(This article belongs to the Special Issue Mechanisms of Heavy Metal Toxicity 2.0)
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Abstract

A toxicogenomic approach was used for toxicity evaluation of arsenic in the aquatic environment, and differential gene expression was investigated from 24 h and 96 h water-only acute toxicity tests with the aquatic oligochaete, Tubifex tubifex (Annelida, Clitellata). Several toxicological endpoints (survival and autotomy) of the oligochaete and tissue residues were measured, and dose-response modelling of gene expression data was studied. A reference transcriptome of the aquatic oligochaete, T. tubifex, was reconstructed for the first time, and genes related to cell stress response (Hsc70, Hsp10, Hsp60, and Hsp83), energy metabolism (COX1), oxidative stress (Cat, GSR, and MnSOD), and the genes involved in the homeostasis of organisms (CaM, RpS13, and UBE2) were identified and characterised. The potential use of the genes identified for risk assessment in freshwater ecosystems as early biomarkers of arsenic toxicity is discussed.
Keywords: arsenic; oligochaeta; toxicity assay; transcriptional biomarker; cell stress response; oxidative stress; homeostasis; effect concentration; reference transcriptome arsenic; oligochaeta; toxicity assay; transcriptional biomarker; cell stress response; oxidative stress; homeostasis; effect concentration; reference transcriptome

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MDPI and ACS Style

Moreno-Ocio, I.; Aquilino, M.; Llorente, L.; Martínez-Madrid, M.; Rodríguez, P.; Méndez-Fernández, L.; Planelló, R. Toxicogenomics of the Freshwater Oligochaete, Tubifex tubifex (Annelida, Clitellata), in Acute Water-Only Exposure to Arsenic. Int. J. Mol. Sci. 2024, 25, 3382. https://doi.org/10.3390/ijms25063382

AMA Style

Moreno-Ocio I, Aquilino M, Llorente L, Martínez-Madrid M, Rodríguez P, Méndez-Fernández L, Planelló R. Toxicogenomics of the Freshwater Oligochaete, Tubifex tubifex (Annelida, Clitellata), in Acute Water-Only Exposure to Arsenic. International Journal of Molecular Sciences. 2024; 25(6):3382. https://doi.org/10.3390/ijms25063382

Chicago/Turabian Style

Moreno-Ocio, Iñigo, Mónica Aquilino, Lola Llorente, Maite Martínez-Madrid, Pilar Rodríguez, Leire Méndez-Fernández, and Rosario Planelló. 2024. "Toxicogenomics of the Freshwater Oligochaete, Tubifex tubifex (Annelida, Clitellata), in Acute Water-Only Exposure to Arsenic" International Journal of Molecular Sciences 25, no. 6: 3382. https://doi.org/10.3390/ijms25063382

APA Style

Moreno-Ocio, I., Aquilino, M., Llorente, L., Martínez-Madrid, M., Rodríguez, P., Méndez-Fernández, L., & Planelló, R. (2024). Toxicogenomics of the Freshwater Oligochaete, Tubifex tubifex (Annelida, Clitellata), in Acute Water-Only Exposure to Arsenic. International Journal of Molecular Sciences, 25(6), 3382. https://doi.org/10.3390/ijms25063382

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