Helicobacter Pylori Virulence Factor Cytotoxin-Associated Gene A (CagA) Induces Vascular Calcification in Coronary Artery Smooth Muscle Cells
Abstract
:1. Introduction
2. Results
2.1. CagA Elicits an Inflammatory Response in CASMCs
2.2. CagA Induces Cyclooxygenase 2 (COX-2) in CASMCs
2.3. CagA Induces Calcification in Vascular Smooth Muscle Cells
3. Discussion
4. Materials and Methods
4.1. Materials
4.2. Cell Culture
4.3. Treatment with H. pylori Virulence Factor CagA
4.4. qPCR
4.5. ELISA
4.6. Calcification Assay
4.7. Statistics
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Sundqvist, M.O.; Wärme, J.; Hofmann, R.; Pawelzik, S.-C.; Bäck, M. Helicobacter Pylori Virulence Factor Cytotoxin-Associated Gene A (CagA) Induces Vascular Calcification in Coronary Artery Smooth Muscle Cells. Int. J. Mol. Sci. 2023, 24, 5392. https://doi.org/10.3390/ijms24065392
Sundqvist MO, Wärme J, Hofmann R, Pawelzik S-C, Bäck M. Helicobacter Pylori Virulence Factor Cytotoxin-Associated Gene A (CagA) Induces Vascular Calcification in Coronary Artery Smooth Muscle Cells. International Journal of Molecular Sciences. 2023; 24(6):5392. https://doi.org/10.3390/ijms24065392
Chicago/Turabian StyleSundqvist, Martin O., Jonatan Wärme, Robin Hofmann, Sven-Christian Pawelzik, and Magnus Bäck. 2023. "Helicobacter Pylori Virulence Factor Cytotoxin-Associated Gene A (CagA) Induces Vascular Calcification in Coronary Artery Smooth Muscle Cells" International Journal of Molecular Sciences 24, no. 6: 5392. https://doi.org/10.3390/ijms24065392
APA StyleSundqvist, M. O., Wärme, J., Hofmann, R., Pawelzik, S.-C., & Bäck, M. (2023). Helicobacter Pylori Virulence Factor Cytotoxin-Associated Gene A (CagA) Induces Vascular Calcification in Coronary Artery Smooth Muscle Cells. International Journal of Molecular Sciences, 24(6), 5392. https://doi.org/10.3390/ijms24065392