Key Role of Mesenchymal Stromal Cell Interaction with Macrophages in Promoting Repair of Lung Injury

Jerkic, Mirjana; Szaszi, Katalin; Laffey, John G.; Rotstein, Ori; Zhang, Haibo

doi:10.3390/ijms24043376

Open AccessReview

Key Role of Mesenchymal Stromal Cell Interaction with Macrophages in Promoting Repair of Lung Injury

by

Mirjana Jerkic

^1,*

,

Katalin Szaszi

^1,2

,

John G. Laffey

^1,3,

Ori Rotstein

^1,2 and

Haibo Zhang

^1,4

¹

The Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, Unity Health Toronto, University of Toronto, Toronto, ON M5B 1T8, Canada

²

Department of Surgery, University of Toronto, Toronto, ON M5T 1P5, Canada

³

Anaesthesia and Intensive Care Medicine, School of Medicine, University of Galway, H91 TK33 Galway, Ireland

⁴

Department of Anesthesiology and Pain Medicine, Interdepartmental Division of Critical Care Medicine and Department of Physiology, University of Toronto, Toronto, ON M5G 1E2, Canada

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2023, 24(4), 3376; https://doi.org/10.3390/ijms24043376

Submission received: 6 January 2023 / Revised: 30 January 2023 / Accepted: 4 February 2023 / Published: 8 February 2023

(This article belongs to the Special Issue Macrophages in Respiratory Diseases)

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Abstract

Lung macrophages (Mφs) are essential for pulmonary innate immunity and host defense due to their dynamic polarization and phenotype shifts. Mesenchymal stromal cells (MSCs) have secretory, immunomodulatory, and tissue-reparative properties and have shown promise in acute and chronic inflammatory lung diseases and in COVID-19. Many beneficial effects of MSCs are mediated through their interaction with resident alveolar and pulmonary interstitial Mφs. Bidirectional MSC-Mφ communication is achieved through direct contact, soluble factor secretion/activation, and organelle transfer. The lung microenvironment facilitates MSC secretion of factors that result in Mφ polarization towards an immunosuppressive M2-like phenotype for the restoration of tissue homeostasis. M2-like Mφ in turn can affect the MSC immune regulatory function in MSC engraftment and tissue reparatory effects. This review article highlights the mechanisms of crosstalk between MSCs and Mφs and the potential role of their interaction in lung repair in inflammatory lung diseases.

Keywords: acute and chronic respiratory diseases; cell therapy; lung immunity and inflammation

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MDPI and ACS Style

Jerkic, M.; Szaszi, K.; Laffey, J.G.; Rotstein, O.; Zhang, H. Key Role of Mesenchymal Stromal Cell Interaction with Macrophages in Promoting Repair of Lung Injury. Int. J. Mol. Sci. 2023, 24, 3376. https://doi.org/10.3390/ijms24043376

AMA Style

Jerkic M, Szaszi K, Laffey JG, Rotstein O, Zhang H. Key Role of Mesenchymal Stromal Cell Interaction with Macrophages in Promoting Repair of Lung Injury. International Journal of Molecular Sciences. 2023; 24(4):3376. https://doi.org/10.3390/ijms24043376

Chicago/Turabian Style

Jerkic, Mirjana, Katalin Szaszi, John G. Laffey, Ori Rotstein, and Haibo Zhang. 2023. "Key Role of Mesenchymal Stromal Cell Interaction with Macrophages in Promoting Repair of Lung Injury" International Journal of Molecular Sciences 24, no. 4: 3376. https://doi.org/10.3390/ijms24043376

APA Style

Jerkic, M., Szaszi, K., Laffey, J. G., Rotstein, O., & Zhang, H. (2023). Key Role of Mesenchymal Stromal Cell Interaction with Macrophages in Promoting Repair of Lung Injury. International Journal of Molecular Sciences, 24(4), 3376. https://doi.org/10.3390/ijms24043376

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Key Role of Mesenchymal Stromal Cell Interaction with Macrophages in Promoting Repair of Lung Injury

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