Non-Coding RNAs in Cell-to-Cell Communication: Exploiting Physiological Mechanisms as Therapeutic Targets in Cardiovascular Pathologies

Laura Francés, Javier; Musolino, Elettra; Papait, Roberto; Pagiatakis, Christina

doi:10.3390/ijms24032205

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Non-Coding RNAs in Cell-to-Cell Communication: Exploiting Physiological Mechanisms as Therapeutic Targets in Cardiovascular Pathologies

by

Javier Laura Francés

¹

,

Elettra Musolino

²

,

Roberto Papait

^1,2 and

Christina Pagiatakis

^1,*

¹

IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy

²

Department of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, Italy

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2023, 24(3), 2205; https://doi.org/10.3390/ijms24032205

Submission received: 13 December 2022 / Revised: 10 January 2023 / Accepted: 14 January 2023 / Published: 22 January 2023

(This article belongs to the Special Issue The Role of Non-coding RNAs Involved in Cardiovascular Diseases and Cellular Communication)

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Abstract

Cardiovascular disease, the leading cause of death worldwide, has been characterized at the molecular level by alterations in gene expression that contribute to the etiology of the disease. Such alterations have been shown to play a critical role in the development of atherosclerosis, cardiac remodeling, and age-related heart failure. Although much is now known about the cellular and molecular mechanisms in this context, the role of epigenetics in the onset of cardiovascular disease remains unclear. Epigenetics, a complex network of mechanisms that regulate gene expression independently of changes to the DNA sequence, has been highly implicated in the loss of homeostasis and the aberrant activation of a myriad of cellular pathways. More specifically, non-coding RNAs have been gaining much attention as epigenetic regulators of various pathologies. In this review, we will provide an overview of the ncRNAs involved in cell-to-cell communication in cardiovascular disease, namely atherosclerosis, cardiac remodeling, and cardiac ageing, and the potential use of epigenetic drugs as novel therapeutic targets.

Keywords: cardiovascular disease; ncRNAs; epigenetics; extracellular vesicles; nanoparticles

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MDPI and ACS Style

Laura Francés, J.; Musolino, E.; Papait, R.; Pagiatakis, C. Non-Coding RNAs in Cell-to-Cell Communication: Exploiting Physiological Mechanisms as Therapeutic Targets in Cardiovascular Pathologies. Int. J. Mol. Sci. 2023, 24, 2205. https://doi.org/10.3390/ijms24032205

AMA Style

Laura Francés J, Musolino E, Papait R, Pagiatakis C. Non-Coding RNAs in Cell-to-Cell Communication: Exploiting Physiological Mechanisms as Therapeutic Targets in Cardiovascular Pathologies. International Journal of Molecular Sciences. 2023; 24(3):2205. https://doi.org/10.3390/ijms24032205

Chicago/Turabian Style

Laura Francés, Javier, Elettra Musolino, Roberto Papait, and Christina Pagiatakis. 2023. "Non-Coding RNAs in Cell-to-Cell Communication: Exploiting Physiological Mechanisms as Therapeutic Targets in Cardiovascular Pathologies" International Journal of Molecular Sciences 24, no. 3: 2205. https://doi.org/10.3390/ijms24032205

APA Style

Laura Francés, J., Musolino, E., Papait, R., & Pagiatakis, C. (2023). Non-Coding RNAs in Cell-to-Cell Communication: Exploiting Physiological Mechanisms as Therapeutic Targets in Cardiovascular Pathologies. International Journal of Molecular Sciences, 24(3), 2205. https://doi.org/10.3390/ijms24032205

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Non-Coding RNAs in Cell-to-Cell Communication: Exploiting Physiological Mechanisms as Therapeutic Targets in Cardiovascular Pathologies

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