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Volume 24
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Case Report

Endometriosis of the Cervix: A Rare Clinical Case with the Possibility of Comparing the Eutopic and Ectopic Endometrium at the Cellular Level

by
Konstantin A. Toniyan
1,2,
Elena Yu. Gorbacheva
1,2,
Valery V. Boyarintsev
3 and
Irina V. Ogneva
2,*
1
Gynecology Department, FGBU KB1 (Volynskaya) UDP RF, 121352 Moscow, Russia
2
Cell Biophysics Lab., State Scientific Center of the Russian Federation Institute of Biomedical Problems of the Russian Academy of Sciences, 123007 Moscow, Russia
3
Emergency and Extreme Medicine Department, FGBU DPO CGMA UDP RF, 121359 Moscow, Russia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(3), 2184; https://doi.org/10.3390/ijms24032184
Submission received: 29 December 2022 / Revised: 19 January 2023 / Accepted: 21 January 2023 / Published: 22 January 2023
(This article belongs to the Special Issue Molecular and Cellular Advances in Endometriosis Research 2.0)
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Abstract

Endometriosis of the cervix is a rare form of genital endometriosis, which is characterized by the appearance of tissue on the vaginal part of the cervix, similar to the tissue of the mucous membrane of the uterine cavity. We describe a clinical case in which we compared the content of cytoskeletal proteins, H3 histone modifications and DNA methylation (total and 5-hydroxymethylcytosine content) in the eutopic endometrium and in tissue from endometriosis foci on the cervix. The patient had elevated levels of estradiol, interleukin-1β and interleukin-8. At the cellular level, the content of tubulin and the marker of stable microtubules were reduced in the ectopic endometrium (by 45% and 37%, p < 0.05, respectively), but the alpha-actinin-1 content was increased (by 75%, p < 0.05) with an increase in the expression of its gene. At the same time, the total level of DNA methylation in the endometriotic focus was reduced by more than 2 times with the accumulation of the intermediate product 5-hydroxymethylcytosine (the content increased by more than 3 times), probably due to an increase in the content of tet methylcytosine dioxygenase 1 (more than 4 times).
Keywords: cervix; cytoskeleton; DNA methylation; endometrium; epigenetics; genital endometriosis cervix; cytoskeleton; DNA methylation; endometrium; epigenetics; genital endometriosis

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MDPI and ACS Style

Toniyan, K.A.; Gorbacheva, E.Y.; Boyarintsev, V.V.; Ogneva, I.V. Endometriosis of the Cervix: A Rare Clinical Case with the Possibility of Comparing the Eutopic and Ectopic Endometrium at the Cellular Level. Int. J. Mol. Sci. 2023, 24, 2184. https://doi.org/10.3390/ijms24032184

AMA Style

Toniyan KA, Gorbacheva EY, Boyarintsev VV, Ogneva IV. Endometriosis of the Cervix: A Rare Clinical Case with the Possibility of Comparing the Eutopic and Ectopic Endometrium at the Cellular Level. International Journal of Molecular Sciences. 2023; 24(3):2184. https://doi.org/10.3390/ijms24032184

Chicago/Turabian Style

Toniyan, Konstantin A., Elena Yu. Gorbacheva, Valery V. Boyarintsev, and Irina V. Ogneva. 2023. "Endometriosis of the Cervix: A Rare Clinical Case with the Possibility of Comparing the Eutopic and Ectopic Endometrium at the Cellular Level" International Journal of Molecular Sciences 24, no. 3: 2184. https://doi.org/10.3390/ijms24032184

APA Style

Toniyan, K. A., Gorbacheva, E. Y., Boyarintsev, V. V., & Ogneva, I. V. (2023). Endometriosis of the Cervix: A Rare Clinical Case with the Possibility of Comparing the Eutopic and Ectopic Endometrium at the Cellular Level. International Journal of Molecular Sciences, 24(3), 2184. https://doi.org/10.3390/ijms24032184

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