Next Article in Journal
Mining TCGA Database for Genes with Prognostic Value in Breast Cancer
Previous Article in Journal
Cirsium Setidens Water Extracts Containing Linarin Block Estrogen Deprivation-Induced Bone Loss in Mice
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 24
Issue 2
10.3390/ijms24021619
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

The Influence of Lactoferrin in Plasma and Peritoneal Fluid on Iron Metabolism in Women with Endometriosis

by
Ewa Skarżyńska
1,*,
Monika Wróbel
2,
Hanna Zborowska
3,
Mateusz Franciszek Kołek
4,
Grzegorz Mańka
5,
Mariusz Kiecka
5,
Michał Lipa
2,
Damian Warzecha
2,
Robert Spaczyński
6,
Piotr Piekarski
7,
Beata Banaszewska
8,
Artur Jakimiuk
9,10,
Tadeusz Issat
11,
Wojciech Rokita
12,13,†,
Jakub Młodawski
12,13,
Maria Szubert
14,15,
Piotr Sieroszewski
14,16,
Grzegorz Raba
17,18,
Kamil Szczupak
17,18,
Tomasz Kluz
19,
Marek Kluza
19,
Mirosław Wielgoś
2,
Barbara Lisowska-Myjak
1 and
Piotr Laudański
2,20,21,22,*add Show full author list remove Hide full author list
1
Department of Biochemistry and Clinical Chemistry, Medical University of Warsaw, 02-097 Warsaw, Poland
2
1st Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-015 Warsaw, Poland
3
Department of Laboratory Medicine, Medical University of Warsaw, 02-097 Warsaw, Poland
4
Faculty of Medicine, Medical University of Vienna, 1090 Vienna, Austria
5
Angelius Provita Hospital, 40-611 Katowice, Poland
6
Center for Gynecology, Obstetrics and Infertility Treatment Pastelova, 60-198 Poznan, Poland
7
Division of Infertility and Reproductive Endocrinology, Department of Gynecology, Obstetrics and Gynecological Oncology, Poznan University of Medical Sciences, 61-701 Poznan, Poland
8
Chair and Department of Laboratory Diagnostics, Poznan University of Medical Sciences, 61-701 Poznan, Poland
9
Department of Reproductive Health, Institute of Mother and Child in Warsaw, 01-211 Warsaw, Poland
10
Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of Interior, 02-507 Warsaw, Poland
11
Department of Obstetrics and Gynecology, Institute of Mother and Child in Warsaw, 01-211 Warsaw, Poland
12
Collegium Medicum, Jan Kochanowski University in Kielce, 02-369 Kielce, Poland
13
Clinic of Obstetrics and Gynecology, Provincial Combined Hospital in Kielce, 25-736 Kielce, Poland
14
Department of Gynecology, Obstetrics Medical University of Lodz, 90-419 Lodz, Poland
15
Department of Surgical Gynecology and Oncology, Medical University of Lodz, 90-419 Lodz, Poland
16
Department of Fetal Medicine and Gynecology, Medical University of Lodz, 90-419 Lodz, Poland
17
Clinic of Obstetric and Gynecology in Przemysl, 37-700 Przemysl, Poland
18
Department of Obstetrics and Gynecology, University of Rzeszow, 35-310 Rzeszow, Poland
19
Department of Gynecology, Gynecology Oncology and Obstetrics, Institute of Medical Sciences, Medical College of Rzeszow University, 35-310 Rzeszow, Poland
20
Department of Obstetrics, Gynecology and Gynecological Oncology, Medical University of Warsaw, 02-091 Warsaw, Poland
21
Women’s Health Research Institute, Calisia University, 62-800 Kalisz, Poland
22
OVIklinika Infertility Center, 01-377 Warsaw, Poland
 
add Show full affiliation list
 
remove Hide full affiliation list
*
Authors to whom correspondence should be addressed.
†
Memorable.
Int. J. Mol. Sci. 2023, 24(2), 1619; https://doi.org/10.3390/ijms24021619
Submission received: 9 December 2022 / Revised: 6 January 2023 / Accepted: 9 January 2023 / Published: 13 January 2023
(This article belongs to the Section Molecular Oncology)
Browse Figures
Versions Notes

Abstract

The aim of this study was to investigate the relationship between lactoferrin and iron and its binding proteins in women with endometriosis by simultaneously measuring these parameters in plasma and peritoneal fluid. Ninety women were evaluated, of whom 57 were confirmed as having endometriosis. Lactoferrin was measured by ELISA, transferrin, ferritin and iron on a Cobas 8000 analyser. Lactoferrin and transferrin in peritoneal fluid were lower compared to plasma, in contrast to ferritin and iron. In plasma, lactoferrin showeds associations with iron and transferrin in endometriosis and with ferritin in the group without endometriosis. Lactoferrin in peritoneal fluid correlated with lactoferrin, iron and transferrin of plasma in patients without endometriosis. The ratio of lactoferrin concentration in peritoneal fluid to plasma differentiated stage I versus IV of endometriosis and was negatively correlated with the iron ratio in patients without endometriosis. The ferritin ratio differentiated women with and without endometriosis. The very high ferritin ratios, especially in advanced stages of endometriosis, suggest the protective involvement of this protein in peritoneal fluid and the loss of this role by lactoferrin. The results demonstrate the validity of assessing iron metabolism in women with endometriosis, which may be useful as a marker of the disease and its progression.
Keywords: ferritin; iron; lactoferrin; transferrin; endometriosis ferritin; iron; lactoferrin; transferrin; endometriosis

Share and Cite

MDPI and ACS Style

Skarżyńska, E.; Wróbel, M.; Zborowska, H.; Kołek, M.F.; Mańka, G.; Kiecka, M.; Lipa, M.; Warzecha, D.; Spaczyński, R.; Piekarski, P.; et al. The Influence of Lactoferrin in Plasma and Peritoneal Fluid on Iron Metabolism in Women with Endometriosis. Int. J. Mol. Sci. 2023, 24, 1619. https://doi.org/10.3390/ijms24021619

AMA Style

Skarżyńska E, Wróbel M, Zborowska H, Kołek MF, Mańka G, Kiecka M, Lipa M, Warzecha D, Spaczyński R, Piekarski P, et al. The Influence of Lactoferrin in Plasma and Peritoneal Fluid on Iron Metabolism in Women with Endometriosis. International Journal of Molecular Sciences. 2023; 24(2):1619. https://doi.org/10.3390/ijms24021619

Chicago/Turabian Style

Skarżyńska, Ewa, Monika Wróbel, Hanna Zborowska, Mateusz Franciszek Kołek, Grzegorz Mańka, Mariusz Kiecka, Michał Lipa, Damian Warzecha, Robert Spaczyński, Piotr Piekarski, and et al. 2023. "The Influence of Lactoferrin in Plasma and Peritoneal Fluid on Iron Metabolism in Women with Endometriosis" International Journal of Molecular Sciences 24, no. 2: 1619. https://doi.org/10.3390/ijms24021619

APA Style

Skarżyńska, E., Wróbel, M., Zborowska, H., Kołek, M. F., Mańka, G., Kiecka, M., Lipa, M., Warzecha, D., Spaczyński, R., Piekarski, P., Banaszewska, B., Jakimiuk, A., Issat, T., Rokita, W., Młodawski, J., Szubert, M., Sieroszewski, P., Raba, G., Szczupak, K., ... Laudański, P. (2023). The Influence of Lactoferrin in Plasma and Peritoneal Fluid on Iron Metabolism in Women with Endometriosis. International Journal of Molecular Sciences, 24(2), 1619. https://doi.org/10.3390/ijms24021619

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop