Microbiota and Glucidic Metabolism: A Link with Multiple Aspects and Perspectives

Round 1

Reviewer 1 Report

In this review, the authors describe the interactions between the gut microbiota and the mechanisms through which it contributes to inflammation, obesity and metabolic diseases.

Comments:

The authors should summarize changes in the gut microbiota in metabolic diseases.

Future developments and limitations of current studies need to be further discussed.

Minor editing of English language required

Author Response

Dear Editor in Chief

And Dear Reviewers

Thank you very much for your revisions.

Please we send the revised manuscript with the following change.

Best regards

Tiziana Ciarambino

MD, PhD

Reviewer 1

In this review, the authors describe the interactions between the gut microbiota and the mechanisms through which it contributes to inflammation, obesity and metabolic diseases.

 Comments:

The authors should summarize changes in the gut microbiota in metabolic diseases.

R: In accordance with the reviewer's suggestions, a section dedicated to changes in the gut microbiota in metabolic diseases has been added to the text.

Future developments and limitations of current studies need to be further discussed.

R: In accordance with the reviewer's suggestions, a section dedicated to the development and limitation to the current study has been added to the text.

Comments on the Quality of English Language Minor editing of English language required

R: In accordance with the reviewer's suggestions, editing of English language

was made

BEST REGARDS

Tiziana Ciarambino

Dear Editor in Chief

And Dear Reviewers

Thank you very much for your revisions.

Please we send the revised manuscript with the following change.

Best regards

Tiziana Ciarambino

MD, PhD

Reviewer 1

In this review, the authors describe the interactions between the gut microbiota and the mechanisms through which it contributes to inflammation, obesity and metabolic diseases.

 Comments:

The authors should summarize changes in the gut microbiota in metabolic diseases.

R: In accordance with the reviewer's suggestions, a section dedicated to changes in the gut microbiota in metabolic diseases has been added to the text.

Future developments and limitations of current studies need to be further discussed.

R: In accordance with the reviewer's suggestions, a section dedicated to the development and limitation to the current study has been added to the text.

Comments on the Quality of English Language Minor editing of English language required

R: In accordance with the reviewer's suggestions, editing of English language

was made

BEST REGARDS

Tiziana Ciarambino

Reviewer 2 Report

The manuscript submitted for publication by Ciarambino et al is an interesting narrative review investigating the topic involving microbiome and glucose metabolism. This is an interesting field with important clinical implications as these relate to obesity, metabolic syndrome and T2DM.

The reviewer would like to offer a few points aiming towards the improvement of the manuscript that the authors may wish to consider:

1. The title would be more direct and less confusing if the authors considered changing "glucidic" to "glucose". The title thus would become more comprehensive and direct.

2. The authors should consider discussing some of the evidence specifically regarding the relationship between the microbiome and Type 2 Diabetes Mellitus a useful recent review to this end is the following:

Sikalidis, A.K.; Maykish, A. The Gut Microbiome and Type 2 Diabetes Mellitus: Discussing A Complex Relationship. Biomedicines 2020, 8, 8. https://doi.org/10.3390/biomedicines8010008.

3. An important aspect that influences glucose metabolism, insulin resistance and subsequently risk for T2DM is body composition. There is also some evidence to suggest that the microbiome may extend some effects in that regard. Signaling through amino acids has been shown to potentially alter the demography of the microbiome and body composition in terms of muscle protein synthesis. In this regard a short discussion about this theme would strengthen the manuscript and would provide a more comprehensive approach especially useful and important for a narrative review. A paper that may be useful to that end is the following:

Maykish, A.; Sikalidis, A.K. Utilization of Hydroxyl-Methyl Butyrate, Leucine, Glutamine and Arginine Supplementation in Nutritional Management of Sarcopenia—Implications and Clinical Considerations for Type 2 Diabetes Mellitus Risk Modulation. J. Pers. Med. 2020, 10, 19. https://doi.org/10.3390/jpm10010019.

English language is OK, proofreading for typos and flow is highly recommended.

Author Response

Dear Editor in Chief

And Dear Reviewers

Thank you very much for your revisions.

Please we send the revised manuscript with the following change.

Best regards

Tiziana Ciarambino

MD, PhD

Reviewer 2

The manuscript submitted for publication by Ciarambino et al is an interesting narrative review investigating the topic involving microbiome and glucose metabolism. This is an interesting field with important clinical implications as these relate to obesity, metabolic syndrome and T2DM.

The reviewer would like to offer a few points aiming towards the improvement of the manuscript that the authors may wish to consider:

1. The title would be more direct and less confusing if the authors considered changing "glucidic" to "glucose". The title thus would become more comprehensive and direct.

R: In accordance with the reviewer's suggestions, the title has been changed.

2. The authors should consider discussing some of the evidence specifically regarding the relationship between the microbiome and Type 2 Diabetes Mellitus a useful recent review to this end is the following:

Sikalidis, A.K.; Maykish, A. The Gut Microbiome and Type 2 Diabetes Mellitus: Discussing A Complex Relationship. Biomedicines 2020, 8, 8. https://doi.org/10.3390/biomedicines8010008.

R: In accordance with the reviewer's suggestions, the relationship between the microbiome and Type has been discussed according to the recommended review.

3. An important aspect that influences glucose metabolism, insulin resistance and subsequently risk for T2DM is body composition. There is also some evidence to suggest that the microbiome may extend some effects in that regard. Signaling through amino acids has been shown to potentially alter the demography of the microbiome and body composition in terms of muscle protein synthesis. In this regard a short discussion about this theme would strengthen the manuscript and would provide a more comprehensive approach especially useful and important for a narrative review. A paper that may be useful to that end is the following:

Maykish, A.; Sikalidis, A.K. Utilization of Hydroxyl-Methyl Butyrate, Leucine, Glutamine and Arginine Supplementation in Nutritional Management of Sarcopenia—Implications and Clinical Considerations for Type 2 Diabetes Mellitus Risk Modulation. J. Pers. Med. 2020, 10, 19. https://doi.org/10.3390/jpm10010019.

R: In accordance with the reviewer's suggestions, the relationship between the role of body composition glucose metabolism, insulin resistance, and subsequently risk for T2DM have been discussed according to the recommended review.

Comments on the Quality of English Language

The English language is OK, proofreading for typos and flow is highly recommended.

R: In accordance with the reviewer's suggestions, editing of the English language was made

Best regards

Tiziana Ciarambino

Round 2

Reviewer 2 Report

The authors have made a reasonable effort in addressing reviewer's points.