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Review

Applications and Opportunities in Using Disulfides, Thiosulfinates, and Thiosulfonates as Antibacterials

by
Lindsay Blume
1,
Timothy E. Long
2 and
Edward Turos
1,*
1
Department of Chemistry, University of South Florida, Tampa, FL 33620, USA
2
Department of Pharmaceutical Sciences, Marshall University, Huntington, WV 25755, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(10), 8659; https://doi.org/10.3390/ijms24108659
Submission received: 19 April 2023 / Revised: 8 May 2023 / Accepted: 9 May 2023 / Published: 12 May 2023
(This article belongs to the Special Issue Latest Review Papers in Biochemistry 2023)
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Abstract

Sulfur-containing molecules have a long history of bioactivity, especially as antibacterial agents in the fight against infectious pathogens. Organosulfur compounds from natural products have been used to treat infections throughout history. Many commercially available antibiotics also have sulfur-based moieties in their structural backbones. In the following review, we summarize sulfur-containing antibacterial compounds, focusing on disulfides, thiosulfinates, and thiosulfonates, and opportunities for future developments in the field.
Keywords: antibiotic; antimicrobial resistance; sulfur; disulfide; thiosulfinate; thiosulfonate antibiotic; antimicrobial resistance; sulfur; disulfide; thiosulfinate; thiosulfonate

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MDPI and ACS Style

Blume, L.; Long, T.E.; Turos, E. Applications and Opportunities in Using Disulfides, Thiosulfinates, and Thiosulfonates as Antibacterials. Int. J. Mol. Sci. 2023, 24, 8659. https://doi.org/10.3390/ijms24108659

AMA Style

Blume L, Long TE, Turos E. Applications and Opportunities in Using Disulfides, Thiosulfinates, and Thiosulfonates as Antibacterials. International Journal of Molecular Sciences. 2023; 24(10):8659. https://doi.org/10.3390/ijms24108659

Chicago/Turabian Style

Blume, Lindsay, Timothy E. Long, and Edward Turos. 2023. "Applications and Opportunities in Using Disulfides, Thiosulfinates, and Thiosulfonates as Antibacterials" International Journal of Molecular Sciences 24, no. 10: 8659. https://doi.org/10.3390/ijms24108659

APA Style

Blume, L., Long, T. E., & Turos, E. (2023). Applications and Opportunities in Using Disulfides, Thiosulfinates, and Thiosulfonates as Antibacterials. International Journal of Molecular Sciences, 24(10), 8659. https://doi.org/10.3390/ijms24108659

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