Next Article in Journal
Isolation of Platelet-Derived Exosomes from Human Platelet-Rich Plasma: Biochemical and Morphological Characterization
Next Article in Special Issue
Cancer-Related Cachexia: The Vicious Circle between Inflammatory Cytokines, Skeletal Muscle, Lipid Metabolism and the Possible Role of Physical Training
Previous Article in Journal
Novel Design of Neuropeptide-Based Drugs with β-Sheet Breaking Potential in Amyloid-Beta Cascade: Molecular and Structural Deciphers
Previous Article in Special Issue
Statins Aggravate the Risk of Insulin Resistance in Human Muscle
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 23
Issue 5
10.3390/ijms23052859
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Leptin in Osteoarthritis and Rheumatoid Arthritis: Player or Bystander?

by
Djedjiga Ait Eldjoudi
1,
Alfonso Cordero Barreal
1,2,
María Gonzalez-Rodríguez
1,2,
Clara Ruiz-Fernández
1,2,
Yousof Farrag
1,
Mariam Farrag
1,
Francisca Lago
3,
Maurizio Capuozzo
4,
Miguel Angel Gonzalez-Gay
5,
Antonio Mera Varela
6,
Jesús Pino
1,† and
Oreste Gualillo
1,*,†
1
SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Research Laboratory 9, Santiago University Clinical Hospital, 15706 Santiago de Compostela, Spain
2
International PhD School, University of Santiago de Compostela (EDIUS), 15706 Santiago de Compostela, Spain
3
Molecular and Cellular Cardiology Group, SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), Research Laboratory 7, Santiago University Clinical Hospital, 15706 Santiago de Compostela, Spain
4
National Health Service, Local Health Authority ASL 3 Napoli Sud, Department of Pharmacy, Ercolano, 80056 Naples, Italy
5
Hospital Universitario Marqués de Valdecilla, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, University of Cantabria, Avenida de Valdecilla s/n, 39011 Santander, Spain
6
SERGAS, Servizo Galego de Saude, Santiago University Clinical Hospital, Division of Rheumatology, 15706 Santiago de Compostela, Spain
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2022, 23(5), 2859; https://doi.org/10.3390/ijms23052859
Submission received: 11 February 2022 / Revised: 28 February 2022 / Accepted: 3 March 2022 / Published: 5 March 2022
(This article belongs to the Special Issue Highlights in Pathophysiology of the Musculoskeletal System)
Browse Figures
Versions Notes

Abstract

White adipose tissue (WAT) is a specialized tissue whose main function is lipid synthesis and triglyceride storage. It is now considered as an active organ secreting a plethora of hormones and cytokines namely adipokines. Discovered in 1994, leptin has emerged as a key molecule with pleiotropic functions. It is primarily recognized for its role in regulating energy homeostasis and food intake. Currently, further evidence suggests its potent role in reproduction, glucose metabolism, hematopoiesis, and interaction with the immune system. It is implicated in both innate and adaptive immunity, and it is reported to contribute, with other adipokines, in the cross-talking networks involved in the pathogenesis of chronic inflammation and immune-related diseases of the musculo-skeletal system such as osteoarthritis (OA) and rheumatoid arthritis (RA). In this review, we summarize the most recent findings concerning the involvement of leptin in immunity and inflammatory responses in OA and RA.
Keywords: leptin; leptin receptor; rheumatoid arthritis; osteoarthritis; inflammation leptin; leptin receptor; rheumatoid arthritis; osteoarthritis; inflammation

Share and Cite

MDPI and ACS Style

Ait Eldjoudi, D.; Cordero Barreal, A.; Gonzalez-Rodríguez, M.; Ruiz-Fernández, C.; Farrag, Y.; Farrag, M.; Lago, F.; Capuozzo, M.; Gonzalez-Gay, M.A.; Mera Varela, A.; et al. Leptin in Osteoarthritis and Rheumatoid Arthritis: Player or Bystander? Int. J. Mol. Sci. 2022, 23, 2859. https://doi.org/10.3390/ijms23052859

AMA Style

Ait Eldjoudi D, Cordero Barreal A, Gonzalez-Rodríguez M, Ruiz-Fernández C, Farrag Y, Farrag M, Lago F, Capuozzo M, Gonzalez-Gay MA, Mera Varela A, et al. Leptin in Osteoarthritis and Rheumatoid Arthritis: Player or Bystander? International Journal of Molecular Sciences. 2022; 23(5):2859. https://doi.org/10.3390/ijms23052859

Chicago/Turabian Style

Ait Eldjoudi, Djedjiga, Alfonso Cordero Barreal, María Gonzalez-Rodríguez, Clara Ruiz-Fernández, Yousof Farrag, Mariam Farrag, Francisca Lago, Maurizio Capuozzo, Miguel Angel Gonzalez-Gay, Antonio Mera Varela, and et al. 2022. "Leptin in Osteoarthritis and Rheumatoid Arthritis: Player or Bystander?" International Journal of Molecular Sciences 23, no. 5: 2859. https://doi.org/10.3390/ijms23052859

APA Style

Ait Eldjoudi, D., Cordero Barreal, A., Gonzalez-Rodríguez, M., Ruiz-Fernández, C., Farrag, Y., Farrag, M., Lago, F., Capuozzo, M., Gonzalez-Gay, M. A., Mera Varela, A., Pino, J., & Gualillo, O. (2022). Leptin in Osteoarthritis and Rheumatoid Arthritis: Player or Bystander? International Journal of Molecular Sciences, 23(5), 2859. https://doi.org/10.3390/ijms23052859

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop