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Volume 23
Issue 5
10.3390/ijms23052598
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Communication

Chemical Compounds Released from Specific Osteoinductive Bioactive Materials Stimulate Human Bone Marrow Mesenchymal Stem Cell Migration

by
Krzysztof Łukowicz
1,
Barbara Zagrajczuk
2,
Karolina Truchan
1,
Łukasz Niedzwiedzki
3,
Katarzyna Cholewa-Kowalska
2 and
Anna M. Osyczka
1,*
1
Department Biology and Cell Imaging, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Gronostajowa 9, 30-387 Krakow, Poland
2
Department of Glass Technology and Amorphous Coatings, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Mickiewicza Ave. 30, 30-059 Krakow, Poland
3
Department of Orthopedics and Physiotherapy, Faculty of Health Sciences, Jagiellonian University Medical College, Kopernika 19e, 31-501 Krakow, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(5), 2598; https://doi.org/10.3390/ijms23052598
Submission received: 20 January 2022 / Revised: 15 February 2022 / Accepted: 23 February 2022 / Published: 26 February 2022
(This article belongs to the Special Issue Animal and Plant Cell–Tissue, Organ Specialization and Function: Investigational, Experimental and Medical Aspects 3.0)
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Abstract

In this work, a poly(L-lactide-co-glycolide) (PLGA)-based composite was enriched with one of the following sol-gel bioactive glasses (SBG) at 50 wt.%: A1—40 mol% SiO2, 60 mol% CaO, CaO/SiO2 ratio of 1.50; S1—80 mol% SiO2, 20 mol% CaO, CaO/SiO2 ratio of 0.25; A2—40 mol% SiO2, 54 mol% CaO, 6 mol% P2O5, CaO/SiO2 ratio of 1.35; S2—80 mol% SiO2,16 mol% CaO, 4 mol% P2O5, CaO/SiO2 ratio of 0.20. The composites and PLGA control sheets were then soaked for 24 h in culture media, and the obtained condition media (CM) were used to treat human bone marrow stromal cells (hBMSCs) for 72 h. All CMs from the composites increased ERK 1/2 activity vs. the control PLGA CM. However, expressions of cell migration-related c-Fos, osteopontin, matrix metalloproteinase-2, C-X-C chemokine receptor type 4, vascular endothelial growth factor, and bone morphogenetic protein 2 were significantly increased only in cells treated with the CM from the A1/PLGA composite. This CM also significantly increased the rate of human BMSC migration but did not affect cell metabolic activity. These results indicate important biological markers that are upregulated by products released from the bioactive composites of a specific chemical composition, which may eventually prompt osteoprogenitor cells to colonize the bioactive material and accelerate the process of tissue regeneration.
Keywords: composites; stem cells; cell migration composites; stem cells; cell migration

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MDPI and ACS Style

Łukowicz, K.; Zagrajczuk, B.; Truchan, K.; Niedzwiedzki, Ł.; Cholewa-Kowalska, K.; Osyczka, A.M. Chemical Compounds Released from Specific Osteoinductive Bioactive Materials Stimulate Human Bone Marrow Mesenchymal Stem Cell Migration. Int. J. Mol. Sci. 2022, 23, 2598. https://doi.org/10.3390/ijms23052598

AMA Style

Łukowicz K, Zagrajczuk B, Truchan K, Niedzwiedzki Ł, Cholewa-Kowalska K, Osyczka AM. Chemical Compounds Released from Specific Osteoinductive Bioactive Materials Stimulate Human Bone Marrow Mesenchymal Stem Cell Migration. International Journal of Molecular Sciences. 2022; 23(5):2598. https://doi.org/10.3390/ijms23052598

Chicago/Turabian Style

Łukowicz, Krzysztof, Barbara Zagrajczuk, Karolina Truchan, Łukasz Niedzwiedzki, Katarzyna Cholewa-Kowalska, and Anna M. Osyczka. 2022. "Chemical Compounds Released from Specific Osteoinductive Bioactive Materials Stimulate Human Bone Marrow Mesenchymal Stem Cell Migration" International Journal of Molecular Sciences 23, no. 5: 2598. https://doi.org/10.3390/ijms23052598

APA Style

Łukowicz, K., Zagrajczuk, B., Truchan, K., Niedzwiedzki, Ł., Cholewa-Kowalska, K., & Osyczka, A. M. (2022). Chemical Compounds Released from Specific Osteoinductive Bioactive Materials Stimulate Human Bone Marrow Mesenchymal Stem Cell Migration. International Journal of Molecular Sciences, 23(5), 2598. https://doi.org/10.3390/ijms23052598

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