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Article

Evidence that Transcriptional Alterations in Sarcoptes scabiei Are under Tight Post-Transcriptional (microRNA) Control

by
Pasi K. Korhonen
1,
Tao Wang
1,
Neil D. Young
1,
Gangi R. Samarawickrama
2,3,
Deepani D. Fernando
2,
Guangxu Ma
1,4,
Robin B. Gasser
1,* and
Katja Fischer
2,*
1
Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC 3010, Australia
2
Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia
3
School of Veterinary Science, University of Queensland, Gatton, QLD 4343, Australia
4
Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(17), 9719; https://doi.org/10.3390/ijms23179719
Submission received: 21 June 2022 / Revised: 19 August 2022 / Accepted: 23 August 2022 / Published: 26 August 2022
(This article belongs to the Special Issue Exploring the Possibility of RNA in Diverse Biological Processes)
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Abstract

Here, we explored transcriptomic differences among early egg (Ee), late egg (Le) and adult female (Af) stages of the scabies mite, Sarcoptes scabiei, using an integrative bioinformatic approach. We recorded a high, negative correlation between miRNAs and genes with decreased mRNA transcription between the developmental stages, indicating substantial post-transcriptional repression; we also showed a positive correlation between miRNAs and genes with increased mRNA transcription, suggesting indirect post-transcriptional regulation. The alterations in mRNA transcription between the egg and adult female stages of S. scabiei were inferred to be linked to metabolism (including carbohydrate and lipid degradation, amino acid and energy metabolism), environmental information processing (e.g., signal transduction and signalling molecules), genetic information processing (e.g., transcription and translation) and/or organismal systems. Taken together, these results provide insight into the transcription of this socioeconomically important parasitic mite, with a particular focus on the egg stage. This work encourages further, detailed laboratory studies of miRNA regulation across all developmental stages of S. scabiei and might assist in discovering new intervention targets in the egg stage of S. scabiei.
Keywords: Sarcoptes scabiei; development; transcription; mRNA; microRNA Sarcoptes scabiei; development; transcription; mRNA; microRNA

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MDPI and ACS Style

Korhonen, P.K.; Wang, T.; Young, N.D.; Samarawickrama, G.R.; Fernando, D.D.; Ma, G.; Gasser, R.B.; Fischer, K. Evidence that Transcriptional Alterations in Sarcoptes scabiei Are under Tight Post-Transcriptional (microRNA) Control. Int. J. Mol. Sci. 2022, 23, 9719. https://doi.org/10.3390/ijms23179719

AMA Style

Korhonen PK, Wang T, Young ND, Samarawickrama GR, Fernando DD, Ma G, Gasser RB, Fischer K. Evidence that Transcriptional Alterations in Sarcoptes scabiei Are under Tight Post-Transcriptional (microRNA) Control. International Journal of Molecular Sciences. 2022; 23(17):9719. https://doi.org/10.3390/ijms23179719

Chicago/Turabian Style

Korhonen, Pasi K., Tao Wang, Neil D. Young, Gangi R. Samarawickrama, Deepani D. Fernando, Guangxu Ma, Robin B. Gasser, and Katja Fischer. 2022. "Evidence that Transcriptional Alterations in Sarcoptes scabiei Are under Tight Post-Transcriptional (microRNA) Control" International Journal of Molecular Sciences 23, no. 17: 9719. https://doi.org/10.3390/ijms23179719

APA Style

Korhonen, P. K., Wang, T., Young, N. D., Samarawickrama, G. R., Fernando, D. D., Ma, G., Gasser, R. B., & Fischer, K. (2022). Evidence that Transcriptional Alterations in Sarcoptes scabiei Are under Tight Post-Transcriptional (microRNA) Control. International Journal of Molecular Sciences, 23(17), 9719. https://doi.org/10.3390/ijms23179719

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