Integrated DNA Copy Number and Expression Profiling Identifies IGF1R as a Prognostic Biomarker in Pediatric Osteosarcoma
Round 1
Reviewer 1 Report
This study is highly relevant for using a large number of samples to investigate molecular biology of osteosarcoma. The amplification of IGFR1 found in this study may in part explain why this cancer occurs so often during periors of rapid bone growth. IGFR1 overexpression can also now be targeted using an antibody (FPI-1434) with an alpha emitter, Ac-225, (NCT03746431). Instead of just saying overexpression is associated with worse prognosis, Suggest also mentioning this clincal trial in the discussion.
Author Response
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Author Response File: Author Response.pdf
Reviewer 2 Report
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Comments for author File: Comments.pdf
Author Response
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Author Response File: Author Response.pdf
Round 2
Reviewer 2 Report
The authors have adequately responded to the reveiwers' comments and I believe the manuscript has improved sufficiently to warrant publication in its present form.