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Article

Amelioration of Cognitive and Behavioral Deficits after Traumatic Brain Injury in Coagulation Factor XII Deficient Mice

1
Department of Neurosurgery, University Hospital of Würzburg, Josef-Schneider-Str. 11, 97080 Würzburg, Germany
2
Department of Neurology, University Hospital of Würzburg, Josef-Schneider-Str. 11, 97080 Würzburg, Germany
3
Department of Neurology and Center for Translational and Behavioral Neurosciences (C-TNBS), University Hospital of Essen, Hufelandstr. 55, 45147 Essen, Germany
4
Institute for Physiology, Department for Neurophysiology, Julius-Maximilians-University Würzburg, Röntgenring 9, 97070 Würzburg, Germany
*
Author to whom correspondence should be addressed.
Present address: Helmholz Institute for RNA-Based Infection Research, Josef-Schneider-Str. 2/D15, 97080 Würzburg, Germany.
Academic Editor: Changjong Moon
Int. J. Mol. Sci. 2021, 22(9), 4855; https://doi.org/10.3390/ijms22094855
Received: 12 April 2021 / Accepted: 1 May 2021 / Published: 3 May 2021
Based on recent findings that show that depletion of factor XII (FXII) leads to better posttraumatic neurological recovery, we studied the effect of FXII-deficiency on post-traumatic cognitive and behavioral outcomes in female and male mice. In agreement with our previous findings, neurological deficits on day 7 after weight-drop traumatic brain injury (TBI) were significantly reduced in FXII−/− mice compared to wild type (WT) mice. Also, glycoprotein Ib (GPIb)-positive platelet aggregates were more frequent in brain microvasculature of WT than FXII−/− mice 3 months after TBI. Six weeks after TBI, memory for novel object was significantly reduced in both female and male WT but not in FXII−/− mice compared to sham-operated mice. In the setting of automated home-cage monitoring of socially housed mice in IntelliCages, female WT mice but not FXII−/− mice showed decreased exploration and reacted negatively to reward extinction one month after TBI. Since neuroendocrine stress after TBI might contribute to trauma-induced cognitive dysfunction and negative emotional contrast reactions, we measured peripheral corticosterone levels and the ration of heart, lung, and spleen weight to bodyweight. Three months after TBI, plasma corticosterone levels were significantly suppressed in both female and male WT but not in FXII−/− mice, while the relative heart weight increased in males but not in females of both phenotypes when compared to sham-operated mice. Our results indicate that FXII deficiency is associated with efficient post-traumatic behavioral and neuroendocrine recovery. View Full-Text
Keywords: closed head injury; contact-kinin system; object recognition memory; IntelliCage; Crespi effect; stress closed head injury; contact-kinin system; object recognition memory; IntelliCage; Crespi effect; stress
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MDPI and ACS Style

Stetter, C.; Lopez-Caperuchipi, S.; Hopp-Krämer, S.; Bieber, M.; Kleinschnitz, C.; Sirén, A.-L.; Albert-Weißenberger, C. Amelioration of Cognitive and Behavioral Deficits after Traumatic Brain Injury in Coagulation Factor XII Deficient Mice. Int. J. Mol. Sci. 2021, 22, 4855. https://doi.org/10.3390/ijms22094855

AMA Style

Stetter C, Lopez-Caperuchipi S, Hopp-Krämer S, Bieber M, Kleinschnitz C, Sirén A-L, Albert-Weißenberger C. Amelioration of Cognitive and Behavioral Deficits after Traumatic Brain Injury in Coagulation Factor XII Deficient Mice. International Journal of Molecular Sciences. 2021; 22(9):4855. https://doi.org/10.3390/ijms22094855

Chicago/Turabian Style

Stetter, Christian, Simon Lopez-Caperuchipi, Sarah Hopp-Krämer, Michael Bieber, Christoph Kleinschnitz, Anna-Leena Sirén, and Christiane Albert-Weißenberger. 2021. "Amelioration of Cognitive and Behavioral Deficits after Traumatic Brain Injury in Coagulation Factor XII Deficient Mice" International Journal of Molecular Sciences 22, no. 9: 4855. https://doi.org/10.3390/ijms22094855

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