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Article

Immunohistochemical Analysis of DNA Repair- and Drug-Efflux-Associated Molecules in Tumor and Peritumor Areas of Glioblastoma

by
Cristiana Angelucci
1,
Alessio D’Alessio
1,*,
Silvia Sorrentino
1,
Filippo Biamonte
2,3,
Umberto Moscato
4,5,
Annunziato Mangiola
6,7,
Gigliola Sica
1 and
Fortunata Iacopino
1
1
Dipartimento di Scienze della Vita e Sanità Pubblica, Sezione di Istologia ed Embriologia, Università Cattolica del Sacro Cuore-Fondazione Policlinico Universitario “Agostino Gemelli”, IRCCS, 00168 Rome, Italy
2
Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Istituto di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
3
Dipartimento di Scienze di Laboratorio e Infettivologiche, Unità Operativa Complessa di Chimica, Biochimica e Biologia Molecolare, Università Cattolica del Sacro Cuore-Fondazione Policlinico Universitario “Agostino Gemelli”, IRCCS, 00168 Rome, Italy
4
Dipartimento di Scienze della Vita e Sanità Pubblica, Sezione di Medicina del Lavoro e Igiene di Sanità Pubblica, Università Cattolica del Sacro Cuore-Fondazione Policlinico Universitario “Agostino Gemelli”, IRCCS, 00168 Rome, Italy
5
Dipartimento delle Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario “A. Gemelli”, IRCCS, 00168 Rome, Italy
6
Unità Operativa Complessa di Neurochirurgia, Ospedale Santo Spirito, 65124 Pescara, Italy
7
Dipartimento di Neuroscienze, Imaging e Scienze Cliniche, Università “G. D’Annunzio”, 66013 Chieti, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(4), 1620; https://doi.org/10.3390/ijms22041620
Submission received: 21 December 2020 / Revised: 24 January 2021 / Accepted: 1 February 2021 / Published: 5 February 2021
(This article belongs to the Special Issue Cell Signaling in Cancer Therapy)
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Abstract

Glioblastoma (GBM), the most commonly occurring primary tumor arising within the central nervous system, is characterized by high invasiveness and poor prognosis. In spite of the improvement in surgical techniques, along with the administration of chemo- and radiation therapy and the incessant investigation in search of prospective therapeutic targets, the local recurrence that frequently occurs within the peritumoral brain tissue makes GBM the most malignant and terminal type of astrocytoma. In the current study, we investigated both GBM and peritumoral tissues obtained from 55 hospitalized patients and the expression of three molecules involved in the onset of resistance/unresponsiveness to chemotherapy: O6-methylguanine methyltransferase (MGMT), breast cancer resistance protein (BCRP1), and A2B5. We propose that the expression of these molecules in the peritumoral tissue might be crucial to promoting the development of early tumorigenic events in the tissue surrounding GBM as well as responsible for the recurrence originating in this apparently normal area and, accordingly, for the resistance to treatment with the standard chemotherapeutic regimen. Notably, the inverse correlation found between MGMT expression in peritumoral tissue and patients’ survival suggests a prognostic role for this protein.
Keywords: glioblastoma; peritumoral area; MGMT; BCRP1; A2B5; chemotherapy; cancer stem cells glioblastoma; peritumoral area; MGMT; BCRP1; A2B5; chemotherapy; cancer stem cells

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MDPI and ACS Style

Angelucci, C.; D’Alessio, A.; Sorrentino, S.; Biamonte, F.; Moscato, U.; Mangiola, A.; Sica, G.; Iacopino, F. Immunohistochemical Analysis of DNA Repair- and Drug-Efflux-Associated Molecules in Tumor and Peritumor Areas of Glioblastoma. Int. J. Mol. Sci. 2021, 22, 1620. https://doi.org/10.3390/ijms22041620

AMA Style

Angelucci C, D’Alessio A, Sorrentino S, Biamonte F, Moscato U, Mangiola A, Sica G, Iacopino F. Immunohistochemical Analysis of DNA Repair- and Drug-Efflux-Associated Molecules in Tumor and Peritumor Areas of Glioblastoma. International Journal of Molecular Sciences. 2021; 22(4):1620. https://doi.org/10.3390/ijms22041620

Chicago/Turabian Style

Angelucci, Cristiana, Alessio D’Alessio, Silvia Sorrentino, Filippo Biamonte, Umberto Moscato, Annunziato Mangiola, Gigliola Sica, and Fortunata Iacopino. 2021. "Immunohistochemical Analysis of DNA Repair- and Drug-Efflux-Associated Molecules in Tumor and Peritumor Areas of Glioblastoma" International Journal of Molecular Sciences 22, no. 4: 1620. https://doi.org/10.3390/ijms22041620

APA Style

Angelucci, C., D’Alessio, A., Sorrentino, S., Biamonte, F., Moscato, U., Mangiola, A., Sica, G., & Iacopino, F. (2021). Immunohistochemical Analysis of DNA Repair- and Drug-Efflux-Associated Molecules in Tumor and Peritumor Areas of Glioblastoma. International Journal of Molecular Sciences, 22(4), 1620. https://doi.org/10.3390/ijms22041620

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