Octacalcium Phosphate for Bone Tissue Engineering: Synthesis, Modification, and In Vitro Biocompatibility Assessment

Teterina, Anastasia Yu.; Smirnov, Igor V.; Fadeeva, Irina S.; Fadeev, Roman S.; Smirnova, Polina V.; Minaychev, Vladislav V.; Kobyakova, Margarita I.; Fedotov, Aleksandr Yu.; Barinov, Sergey M.; Komlev, Vladimir S.

doi:10.3390/ijms222312747

Open AccessArticle

Octacalcium Phosphate for Bone Tissue Engineering: Synthesis, Modification, and In Vitro Biocompatibility Assessment

by

Anastasia Yu. Teterina

^1,*,

Igor V. Smirnov

¹,

Irina S. Fadeeva

^1,2,*

,

Roman S. Fadeev

²,

Polina V. Smirnova

¹,

Vladislav V. Minaychev

^1,2,

Margarita I. Kobyakova

^1,2,

Aleksandr Yu. Fedotov

¹,

Sergey M. Barinov

¹ and

Vladimir S. Komlev

^1,*

¹

A.A. Baikov Institute of Metallurgy and Material Science Russian Academy of Sciences, Leninskiy Prospect 49, 117334 Moscow, Russia

²

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Russia

^*

Authors to whom correspondence should be addressed.

Int. J. Mol. Sci. 2021, 22(23), 12747; https://doi.org/10.3390/ijms222312747

Submission received: 19 October 2021 / Revised: 17 November 2021 / Accepted: 23 November 2021 / Published: 25 November 2021

(This article belongs to the Special Issue Optimization of Biomaterials for Reconstructive and Regenerative Medicine)

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Abstract

Octacalcium phosphate (OCP, Ca₈H₂(PO₄)₆·5H₂O) is known to be a possible precursor of biological hydroxyapatite formation of organic bone tissue. OCP has higher biocompatibility and osseointegration rate compared to other calcium phosphates. In this work, the synthesis of low-temperature calcium phosphate compounds and substituted forms of those at physiological temperatures is shown. Strontium is used to improve bioactive properties of the material. Strontium was inserted into the OCP structure by ionic substitution in solutions. The processes of phase formation of low-temperature OCP with theoretical substitution of strontium for calcium up to 50 at.% in conditions close to physiological, i.e., temperature 35–37 °C and normal pressure, were described. The effect of strontium substitution range on changes in the crystal lattice of materials, the microstructural features, surface morphology and biological properties in vitro has been established. The results of the study indicate the effectiveness of using strontium in OCP for improving biocompatibility of OCP based composite materials intended for bone repair.

Keywords: biocompatible materials; calcium phosphate compounds; hydroxyapatite; octacalcium phosphate; bone tissue regeneration; biomineralization

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MDPI and ACS Style

Teterina, A.Y.; Smirnov, I.V.; Fadeeva, I.S.; Fadeev, R.S.; Smirnova, P.V.; Minaychev, V.V.; Kobyakova, M.I.; Fedotov, A.Y.; Barinov, S.M.; Komlev, V.S. Octacalcium Phosphate for Bone Tissue Engineering: Synthesis, Modification, and In Vitro Biocompatibility Assessment. Int. J. Mol. Sci. 2021, 22, 12747. https://doi.org/10.3390/ijms222312747

AMA Style

Teterina AY, Smirnov IV, Fadeeva IS, Fadeev RS, Smirnova PV, Minaychev VV, Kobyakova MI, Fedotov AY, Barinov SM, Komlev VS. Octacalcium Phosphate for Bone Tissue Engineering: Synthesis, Modification, and In Vitro Biocompatibility Assessment. International Journal of Molecular Sciences. 2021; 22(23):12747. https://doi.org/10.3390/ijms222312747

Chicago/Turabian Style

Teterina, Anastasia Yu., Igor V. Smirnov, Irina S. Fadeeva, Roman S. Fadeev, Polina V. Smirnova, Vladislav V. Minaychev, Margarita I. Kobyakova, Aleksandr Yu. Fedotov, Sergey M. Barinov, and Vladimir S. Komlev. 2021. "Octacalcium Phosphate for Bone Tissue Engineering: Synthesis, Modification, and In Vitro Biocompatibility Assessment" International Journal of Molecular Sciences 22, no. 23: 12747. https://doi.org/10.3390/ijms222312747

APA Style

Teterina, A. Y., Smirnov, I. V., Fadeeva, I. S., Fadeev, R. S., Smirnova, P. V., Minaychev, V. V., Kobyakova, M. I., Fedotov, A. Y., Barinov, S. M., & Komlev, V. S. (2021). Octacalcium Phosphate for Bone Tissue Engineering: Synthesis, Modification, and In Vitro Biocompatibility Assessment. International Journal of Molecular Sciences, 22(23), 12747. https://doi.org/10.3390/ijms222312747

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Octacalcium Phosphate for Bone Tissue Engineering: Synthesis, Modification, and In Vitro Biocompatibility Assessment

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