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Cell Behavior of Non-Small Cell Lung Cancer Is at EGFR and MicroRNAs Hands

1
Biotechnology Program, Basic and Applied Sciences (BAS) Institute, Egypt-Japan University of Science and Technology (E-JUST), Alexandria 21934, Egypt
2
Department of Zoology, Faculty of Science, Cairo University, Giza 12613, Egypt
*
Author to whom correspondence should be addressed.
The authors have contributed equally to this work and senior authorship.
Academic Editor: Carlo Genova
Int. J. Mol. Sci. 2021, 22(22), 12496; https://doi.org/10.3390/ijms222212496
Received: 1 November 2021 / Revised: 13 November 2021 / Accepted: 17 November 2021 / Published: 19 November 2021
Lung cancer is a complex disease associated with gene mutations, particularly mutations of Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) and epidermal growth factor receptor (EGFR). Non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) are the two major types of lung cancer. The former includes most lung cancers (85%) and are commonly associated with EGFR mutations. Several EGFR-tyrosine kinase inhibitors (EGFR-TKIs), including erlotinib, gefitinib, and osimertinib, are effective therapeutic agents in EGFR-mutated NSCLC. However, their effectiveness is limited by the development (acquired) or presence of intrinsic drug resistance. MicroRNAs (miRNAs) are key gene regulators that play a profound role in the development and outcomes for NSCLC via their role as oncogenes or oncosuppressors. The regulatory role of miRNA-dependent EGFR crosstalk depends on EGFR signaling pathway, including Rat Sarcoma/Rapidly Accelerated Fibrosarcoma/Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase 1/2 (Ras/Raf/MEK/ERK1/2), Signal Transducer and Activator of Transcription (STAT), Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-kB), phosphoinositide 3-kinase/protein kinase B (PI3K/AKT), Janus kinase 1 (JAK1), and growth factor receptor-bound protein 2 (GRB2). Dysregulated expression of miRNAs affects sensitivity to treatment with EGFR-TKIs. Thus, abnormalities in miRNA-dependent EGFR crosstalk can be used as diagnostic and prognostic markers, as well as therapeutic targets in NSCLC. In this review, we present an overview of miRNA-dependent EGFR expression regulation, which modulates the behavior and progression of NSCLC. View Full-Text
Keywords: epidermal growth factor receptor (EGFR); microRNA (miRNA); therapeutic targets; diagnostic markers; signaling pathways; oncogenes; oncosuppressors; chemoresistance; tyrosine kinase inhibitors (TKIs); non-small cell lung cancer (NSCLC) epidermal growth factor receptor (EGFR); microRNA (miRNA); therapeutic targets; diagnostic markers; signaling pathways; oncogenes; oncosuppressors; chemoresistance; tyrosine kinase inhibitors (TKIs); non-small cell lung cancer (NSCLC)
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MDPI and ACS Style

Hassanein, S.S.; Ibrahim, S.A.; Abdel-Mawgood, A.L. Cell Behavior of Non-Small Cell Lung Cancer Is at EGFR and MicroRNAs Hands. Int. J. Mol. Sci. 2021, 22, 12496. https://doi.org/10.3390/ijms222212496

AMA Style

Hassanein SS, Ibrahim SA, Abdel-Mawgood AL. Cell Behavior of Non-Small Cell Lung Cancer Is at EGFR and MicroRNAs Hands. International Journal of Molecular Sciences. 2021; 22(22):12496. https://doi.org/10.3390/ijms222212496

Chicago/Turabian Style

Hassanein, Sarah S., Sherif A. Ibrahim, and Ahmed L. Abdel-Mawgood. 2021. "Cell Behavior of Non-Small Cell Lung Cancer Is at EGFR and MicroRNAs Hands" International Journal of Molecular Sciences 22, no. 22: 12496. https://doi.org/10.3390/ijms222212496

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