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Article

Tetrahexyldecyl Ascorbate (THDC) Degrades Rapidly under Oxidative Stress but Can Be Stabilized by Acetyl Zingerone to Enhance Collagen Production and Antioxidant Effects

1
Department of Internal Medicine, The Jewish Hospital, Cincinnati, OH 45236, USA
2
Sytheon Ltd., Boonton, NJ 07005, USA
3
Sunny BioDiscovery Inc., Santa Paula, CA 93060, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Edwin Lephart
Int. J. Mol. Sci. 2021, 22(16), 8756; https://doi.org/10.3390/ijms22168756
Received: 13 July 2021 / Revised: 8 August 2021 / Accepted: 9 August 2021 / Published: 15 August 2021
(This article belongs to the Section Bioactives and Nutraceuticals)
Tetrahexyldecyl Ascorbate (THDC) is an L-ascorbic acid precursor with improved stability and ability to penetrate the epidermis. The stability and transdermal penetration of THDC, however, may be compromised by the oxidant-rich environment of human skin. In this study, we show that THDC is a poor antioxidant that degrades rapidly when exposed to singlet oxygen. This degradation, however, was prevented by combination with acetyl zingerone (AZ) as a stabilizing antioxidant. As a standalone ingredient, THDC led to unexpected activation of type I interferon signaling, but this pro-inflammatory effect was blunted in the presence of AZ. Moreover, the combination of THDC and AZ increased expression of genes associated with phospholipid homeostasis and keratinocyte differentiation, along with repression of MMP1 and MMP7 expression, inhibition of MMP enzyme activity, and increased production of collagen proteins by dermal fibroblasts. Lastly, whereas THDC alone reduced viability of keratinocytes exposed to oxidative stress, this effect was completely abrogated by the addition of AZ to THDC. These results show that AZ is an effective antioxidant stabilizer of THDC and that combination of these products may improve ascorbic acid delivery. This provides a step towards reaching the full potential of ascorbate as an active ingredient in topical preparations. View Full-Text
Keywords: acetyl zingerone; ascorbate; collagen; skin aging; tetrahexyldecyl ascorbate; vitamin C acetyl zingerone; ascorbate; collagen; skin aging; tetrahexyldecyl ascorbate; vitamin C
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MDPI and ACS Style

Swindell, W.R.; Randhawa, M.; Quijas, G.; Bojanowski, K.; Chaudhuri, R.K. Tetrahexyldecyl Ascorbate (THDC) Degrades Rapidly under Oxidative Stress but Can Be Stabilized by Acetyl Zingerone to Enhance Collagen Production and Antioxidant Effects. Int. J. Mol. Sci. 2021, 22, 8756. https://doi.org/10.3390/ijms22168756

AMA Style

Swindell WR, Randhawa M, Quijas G, Bojanowski K, Chaudhuri RK. Tetrahexyldecyl Ascorbate (THDC) Degrades Rapidly under Oxidative Stress but Can Be Stabilized by Acetyl Zingerone to Enhance Collagen Production and Antioxidant Effects. International Journal of Molecular Sciences. 2021; 22(16):8756. https://doi.org/10.3390/ijms22168756

Chicago/Turabian Style

Swindell, William R., Manpreet Randhawa, Geovani Quijas, Krzysztof Bojanowski, and Ratan K. Chaudhuri. 2021. "Tetrahexyldecyl Ascorbate (THDC) Degrades Rapidly under Oxidative Stress but Can Be Stabilized by Acetyl Zingerone to Enhance Collagen Production and Antioxidant Effects" International Journal of Molecular Sciences 22, no. 16: 8756. https://doi.org/10.3390/ijms22168756

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