Microglia and the Aging Brain: Are Geriatric Microglia Linked to Poor Sleep Quality?
Abstract
:1. Introduction
2. Microglia and Their Role in Normal Adult Brain
3. Sleep–Wake Cycle Impact on Microglia–Synapse Interaction
4. Diurnal Rhythmicity in Microglial Structure
5. Diurnal Rhythmicity in Microglial Interactions with Neurons and Neuronal Elements
6. Diurnal Rhythmicity in the Expression of Genes Related to Microglial Phagocytosis
7. Diurnal Rhythmicity in the Expression of Genes Related to Microglial Inflammation
8. Extrinsic Cellular Factors behind Microglial Rhythmicity
9. Intrinsic Molecular Clocks behind Microglial Rhythmicity
10. Alteration of Clock Genes Changes the Microglial Phenotype
11. Senescent Microglia
12. Diurnal Rhythmicity of Senescent Microglia
13. Sleep Characteristics in Aged Rodents
14. Senescent Microglia and Their Impact on Sleep
15. Effect of Sleep Loss on Microglial Senescence
16. Effects of Commonly Used Drugs for Sleep Disorders on Microglial Performances
17. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Choudhury, M.E.; Miyanishi, K.; Takeda, H.; Tanaka, J. Microglia and the Aging Brain: Are Geriatric Microglia Linked to Poor Sleep Quality? Int. J. Mol. Sci. 2021, 22, 7824. https://doi.org/10.3390/ijms22157824
Choudhury ME, Miyanishi K, Takeda H, Tanaka J. Microglia and the Aging Brain: Are Geriatric Microglia Linked to Poor Sleep Quality? International Journal of Molecular Sciences. 2021; 22(15):7824. https://doi.org/10.3390/ijms22157824
Chicago/Turabian StyleChoudhury, Mohammed E., Kazuya Miyanishi, Haruna Takeda, and Junya Tanaka. 2021. "Microglia and the Aging Brain: Are Geriatric Microglia Linked to Poor Sleep Quality?" International Journal of Molecular Sciences 22, no. 15: 7824. https://doi.org/10.3390/ijms22157824