Review Reports

Round 1

Reviewer 1 Report

This review is of interest, updated and well written. 

The only suggestion concerns the title. Since half of the review describes the role of sclerostin in regulating bone mineralization, I would suggest to modify the title including both bone and ectopic mineralization (two sides of the same coin).

Author Response

We would thank you for carefully reading this manuscript.

We have adapted the title as you suggested ('The role of sclerostin in bone and ectopic calcification').

Reviewer 2 Report

This review on sclerostin is a comprehensive, extensive and thorough overview of the up-to-date knowledge on this important molecule. The authors have gathered loads of information on the topic, illustrated by the number of refs, yet made the article clear, comprehensible, and, taking into consideration the complexity of the featured issue, relatively easy to follow. The text is accompanied by figures that, although simple, sufficiently illustrate the information provided in the manuscript. I have read it with pleasure.

Author Response

We would like to thank you for carefully reading this manuscript.

Based on the suggestion of the other reviewer, we have adapted the title ('The role of sclerostin in bone and ectopic calcification').