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The Contribution of Astrocyte Autophagy to Systemic Metabolism

Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), 28002 Madrid, Spain
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(7), 2479;
Received: 27 February 2020 / Revised: 20 March 2020 / Accepted: 2 April 2020 / Published: 3 April 2020
(This article belongs to the Special Issue Autophagy in Health, Ageing and Disease)
Autophagy is an essential mechanism to maintain cellular homeostasis. Besides its role in controlling the quality of cytoplasmic components, it participates in nutrient obtaining and lipid mobilization under stressful conditions. Furthermore, autophagy is involved in the regulation of systemic metabolism as its blockade in hypothalamic neurons can affect the central regulation of metabolism and impact body energy balance. Moreover, hypothalamic autophagy can be altered during obesity, one of the main alterations of metabolism nowadays. In this review, we focus on the role of astrocytes, essential cells for brain homeostasis, which represent key metabolic regulators. Astrocytes can sense metabolic signals in the hypothalamus and modulate systemic functions as glucose homeostasis and feeding response. Moreover, the response of astrocytes to obesity has been widely studied. Astrocytes are important mediators of brain inflammation and can be affected by increased levels of saturated fatty acids associated with obesity. Although autophagy plays important roles for astrocyte homeostasis and functioning, the contribution of astrocyte autophagy to systemic metabolism has not been analyzed yet. Furthermore, how obesity can impact astrocyte autophagy is poorly understood. More studies are needed in order to understand the contribution of astrocyte autophagy to metabolism. View Full-Text
Keywords: astrocytes; autophagy; hypothalamus; metabolism; obesity astrocytes; autophagy; hypothalamus; metabolism; obesity
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MDPI and ACS Style

Ortiz-Rodriguez, A.; Arevalo, M.-A. The Contribution of Astrocyte Autophagy to Systemic Metabolism. Int. J. Mol. Sci. 2020, 21, 2479.

AMA Style

Ortiz-Rodriguez A, Arevalo M-A. The Contribution of Astrocyte Autophagy to Systemic Metabolism. International Journal of Molecular Sciences. 2020; 21(7):2479.

Chicago/Turabian Style

Ortiz-Rodriguez, Ana, and Maria-Angeles Arevalo. 2020. "The Contribution of Astrocyte Autophagy to Systemic Metabolism" International Journal of Molecular Sciences 21, no. 7: 2479.

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