Next Article in Journal
Pituitary Hyperplasia, Hormonal Changes and Prolactinoma Development in Males Exposed to Estrogens—An Insight From Translational Studies
Next Article in Special Issue
The Contribution of Astrocyte Autophagy to Systemic Metabolism
Previous Article in Journal
The Impact of Natural Compounds on S-Shaped Aβ42 Fibril: From Molecular Docking to Biophysical Characterization
Previous Article in Special Issue
The Autophagy Regulatory Molecule CSRP3 Interacts with LC3 and Protects Against Muscular Dystrophy
Article

Role of Autophagy in Von Willebrand Factor Secretion by Endothelial Cells and in the In Vivo Thrombin-Antithrombin Complex Formation Promoted by the HIV-1 Matrix Protein p17

1
Department of Molecular and Translational Medicine, Section of Microbiology, University of Brescia Medical School, 25123 Brescia, Italy
2
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy
3
Helmholtz Center for Infection Research (HZI), Department of Vaccinology and Applied Microbiology, 38124 Braunschweig, Germany
4
Cardiovascular Program ICCC, CiberCV, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain
5
John Dalton Building, School of Healthcare Science, Manchester Metropolitan University, Manchester M1 5GD, UK
*
Author to whom correspondence should be addressed.
These authors have contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(6), 2022; https://doi.org/10.3390/ijms21062022
Received: 22 November 2019 / Revised: 29 February 2020 / Accepted: 11 March 2020 / Published: 16 March 2020
(This article belongs to the Special Issue Autophagy in Health, Ageing and Disease)
Although the advent of combined antiretroviral therapy has substantially improved the survival of HIV-1-infected individuals, non-AIDS-related diseases are becoming increasingly prevalent in HIV-1-infected patients. Persistent abnormalities in coagulation appear to contribute to excess risk for a broad spectrum of non-AIDS defining complications. Alterations in coagulation biology in the context of HIV infection seem to be largely a consequence of a chronically inflammatory microenvironment leading to endothelial cell (EC) dysfunction. A possible direct role of HIV-1 proteins in sustaining EC dysfunction has been postulated but not yet investigated. The HIV-1 matrix protein p17 (p17) is secreted from HIV-1-infected cells and is known to sustain inflammatory processes by activating ECs. The aim of this study was to investigate the possibility that p17-driven stimulation of human ECs is associated with increased production of critical coagulation factors. Here we show the involvement of autophagy in the p17-induced accumulation and secretion of von Willebrand factor (vWF) by ECs. In vivo experiments confirmed the capability of p17 to exert a potent pro-coagulant activity soon after its intravenous administration. View Full-Text
Keywords: HIV-1; p17 matrix protein; coagulation; thrombin-antithrombin complex; AIDS-related diseases; autophagy HIV-1; p17 matrix protein; coagulation; thrombin-antithrombin complex; AIDS-related diseases; autophagy
Show Figures

Figure 1

MDPI and ACS Style

Bugatti, A.; Marsico, S.; Mazzuca, P.; Schulze, K.; Ebensen, T.; Giagulli, C.; Peña, E.; Badimón, L.; Slevin, M.; Caruso, A.; Guzman, C.A.; Caccuri, F. Role of Autophagy in Von Willebrand Factor Secretion by Endothelial Cells and in the In Vivo Thrombin-Antithrombin Complex Formation Promoted by the HIV-1 Matrix Protein p17. Int. J. Mol. Sci. 2020, 21, 2022. https://doi.org/10.3390/ijms21062022

AMA Style

Bugatti A, Marsico S, Mazzuca P, Schulze K, Ebensen T, Giagulli C, Peña E, Badimón L, Slevin M, Caruso A, Guzman CA, Caccuri F. Role of Autophagy in Von Willebrand Factor Secretion by Endothelial Cells and in the In Vivo Thrombin-Antithrombin Complex Formation Promoted by the HIV-1 Matrix Protein p17. International Journal of Molecular Sciences. 2020; 21(6):2022. https://doi.org/10.3390/ijms21062022

Chicago/Turabian Style

Bugatti, Antonella, Stefania Marsico, Pietro Mazzuca, Kai Schulze, Thomas Ebensen, Cinzia Giagulli, Esther Peña, Lina Badimón, Mark Slevin, Arnaldo Caruso, Carlos A. Guzman, and Francesca Caccuri. 2020. "Role of Autophagy in Von Willebrand Factor Secretion by Endothelial Cells and in the In Vivo Thrombin-Antithrombin Complex Formation Promoted by the HIV-1 Matrix Protein p17" International Journal of Molecular Sciences 21, no. 6: 2022. https://doi.org/10.3390/ijms21062022

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop