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Review

The Basic Properties of Gold Nanoparticles and their Applications in Tumor Diagnosis and Treatment

1
School of Mechanical Engineering & Automation, Beihang University, Beijing 100191, China
2
Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100083, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(7), 2480; https://doi.org/10.3390/ijms21072480
Received: 12 March 2020 / Revised: 29 March 2020 / Accepted: 1 April 2020 / Published: 3 April 2020
(This article belongs to the Special Issue Nanomaterials for Pro-/Anti-Angiogenic Therapies)
Gold nanoparticles (AuNPs) have been widely studied and applied in the field of tumor diagnosis and treatment because of their special fundamental properties. In order to make AuNPs more suitable for tumor diagnosis and treatment, their natural properties and the interrelationships between these properties should be systematically and profoundly understood. The natural properties of AuNPs were discussed from two aspects: physical and chemical. Among the physical properties of AuNPs, localized surface plasmon resonance (LSPR), radioactivity and high X-ray absorption coefficient are widely used in the diagnosis and treatment of tumors. As an advantage over many other nanoparticles in chemicals, AuNPs can form stable chemical bonds with S-and N-containing groups. This allows AuNPs to attach to a wide variety of organic ligands or polymers with a specific function. These surface modifications endow AuNPs with outstanding biocompatibility, targeting and drug delivery capabilities. In this review, we systematically summarized the physicochemical properties of AuNPs and their intrinsic relationships. Then the latest research advancements and the developments of basic research and clinical trials using these properties are summarized. Further, the difficulties to be overcome and possible solutions in the process from basic laboratory research to clinical application are discussed. Finally, the possibility of applying the results to clinical trials was estimated. We hope to provide a reference for peer researchers to better utilize the excellent physicochemical properties of gold nanoparticles in oncotherapy. View Full-Text
Keywords: gold nanoparticle; tumor diagnosis and treatment; cancer nanotechnology; drug delivery gold nanoparticle; tumor diagnosis and treatment; cancer nanotechnology; drug delivery
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MDPI and ACS Style

Bai, X.; Wang, Y.; Song, Z.; Feng, Y.; Chen, Y.; Zhang, D.; Feng, L. The Basic Properties of Gold Nanoparticles and their Applications in Tumor Diagnosis and Treatment. Int. J. Mol. Sci. 2020, 21, 2480. https://doi.org/10.3390/ijms21072480

AMA Style

Bai X, Wang Y, Song Z, Feng Y, Chen Y, Zhang D, Feng L. The Basic Properties of Gold Nanoparticles and their Applications in Tumor Diagnosis and Treatment. International Journal of Molecular Sciences. 2020; 21(7):2480. https://doi.org/10.3390/ijms21072480

Chicago/Turabian Style

Bai, Xue, Yueying Wang, Zhiyun Song, Yanmin Feng, Yuanyuan Chen, Deyuan Zhang, and Lin Feng. 2020. "The Basic Properties of Gold Nanoparticles and their Applications in Tumor Diagnosis and Treatment" International Journal of Molecular Sciences 21, no. 7: 2480. https://doi.org/10.3390/ijms21072480

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