Next Article in Journal
Regulative Loop between β-catenin and Protein Tyrosine Receptor Type γ in Chronic Myeloid Leukemia
Next Article in Special Issue
Curcumin and Colorectal Cancer: From Basic to Clinical Evidences
Previous Article in Journal
Simple Selection Procedure to Distinguish between Static and Flexible Loops
Previous Article in Special Issue
Curcumin in Health and Diseases: Alzheimer’s Disease and Curcumin Analogues, Derivatives, and Hybrids

This is an early access version, the complete PDF, HTML, and XML versions will be available soon.

Open AccessReview

The Emerging Role of Curcumin in the Modulation of TLR-4 Signaling Pathway: Focus on Neuroprotective and Anti-Rheumatic Properties

1
Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, 70125 Bari, Italy
2
Rheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia, 71121 Foggia, Italy
3
College of Medicine, Department of Biomedical Sciences, King Faisal University, 31982, Al-Ahsa, Saudi Arabia
4
Department of Clinical and Experimental Medicine, University of Foggia, 71121 Foggia, Italy
*
Author to whom correspondence should be addressed.
These authors equally contributed to this work
Int. J. Mol. Sci. 2020, 21(7), 2299; https://doi.org/10.3390/ijms21072299 (registering DOI)
Received: 31 January 2020 / Revised: 25 February 2020 / Accepted: 24 March 2020 / Published: 26 March 2020
(This article belongs to the Special Issue Curcumin in Health and Disease: New Knowledge)
Natural products have been used in medicine for thousands of years. Given their potential health benefits, they have gained significant popularity in recent times. The administration of phytochemicals existed shown to regulate differential gene expression and modulate various cellular pathways implicated in cell protection. Curcumin is a natural dietary polyphenol extracted from Curcuma Longa Linn with different biological and pharmacological effects. One of the important targets of curcumin is Toll-like receptor-4 (TLR-4), the receptor which plays a key role in the modulation of the immune responses and the stimulation of inflammatory chemokines and cytokines production. Different studies have demonstrated that curcumin attenuates inflammatory response via TLR-4 acting directly on receptor, or by its downstream pathway. Curcumin bioavailability is low, so the use of exosomes, as nano drug delivery, could improve the efficacy of curcumin in inflammatory diseases. The focus of this review is to explore the therapeutic effect of curcumin interacting with TLR-4 receptor and how this modulation could improve the prognosis of neuroinflammatory and rheumatic diseases.
Keywords: Curcumin; TLR-4; Neuroinflammatory diseases; Rheumatic Diseases; miRNA; exosomes Curcumin; TLR-4; Neuroinflammatory diseases; Rheumatic Diseases; miRNA; exosomes
MDPI and ACS Style

Panaro, M.A.; Corrado, A.; Benameur, T.; Paolo, C.F.; Cici, D.; Porro, C. The Emerging Role of Curcumin in the Modulation of TLR-4 Signaling Pathway: Focus on Neuroprotective and Anti-Rheumatic Properties. Int. J. Mol. Sci. 2020, 21, 2299.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop