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Article

Hericium Erinaceus Prevents DEHP-Induced Mitochondrial Dysfunction and Apoptosis in PC12 Cells

1
Laboratory for Research on Biologically Compatible Compounds, Faculty of Dental Medicine, University of Monastir, Rue Avicenne, Monastir 5019, Tunisia
2
Department of Biomedical and Biotechnological Sciences, University of Catania, Torre Biologica, Via Santa Sofia n. 97, 95125 Catania, Italy
3
Department of Medical and Surgery Sciences, University of Catania, 95125, Via Santa Sofia, 78, 95123 Catania, Italy
4
Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Piazza G. Cesare, 11, 70124 Bari, Italy
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(6), 2138; https://doi.org/10.3390/ijms21062138
Received: 10 February 2020 / Revised: 16 March 2020 / Accepted: 17 March 2020 / Published: 20 March 2020
Hericium Erinaceus (HE) is a medicinal plant known to possess anticarcinogenic, antibiotic, and antioxidant activities. It has been shown to have a protective effect against ischemia-injury-induced neuronal cell death in rats. As an extending study, here we examined in pheochromocytoma 12 (PC12) cells, whether HE could exert a protective effect against oxidative stress and apoptosis induced by di(2-ethylhexyl)phthalate (DEHP), a plasticizer known to cause neurotoxicity. We demonstrated that pretreatment with HE significantly attenuated DEHP induced cell death. This protective effect may be attributed to its ability to reduce intracellular reactive oxygen species levels, preserving the activity of respiratory complexes and stabilizing the mitochondrial membrane potential. Additionally, HE pretreatment significantly modulated Nrf2 and Nrf2-dependent vitagenes expression, preventing the increase of pro-apoptotic and the decrease of anti-apoptotic markers. Collectively, our data provide evidence of new preventive nutritional strategy using HE against DEHP-induced apoptosis in PC12 cells. View Full-Text
Keywords: Di (2-Ethylhexyl) pthalate; Hericium erinaceus; vitagenes; oxidative stress; apoptosis; mitochondrial respiratory complexes Di (2-Ethylhexyl) pthalate; Hericium erinaceus; vitagenes; oxidative stress; apoptosis; mitochondrial respiratory complexes
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MDPI and ACS Style

Amara, I.; Scuto, M.; Zappalà, A.; Ontario, M.L.; Petralia, A.; Abid-Essefi, S.; Maiolino, L.; Signorile, A.; Trovato Salinaro, A.; Calabrese, V. Hericium Erinaceus Prevents DEHP-Induced Mitochondrial Dysfunction and Apoptosis in PC12 Cells. Int. J. Mol. Sci. 2020, 21, 2138. https://doi.org/10.3390/ijms21062138

AMA Style

Amara I, Scuto M, Zappalà A, Ontario ML, Petralia A, Abid-Essefi S, Maiolino L, Signorile A, Trovato Salinaro A, Calabrese V. Hericium Erinaceus Prevents DEHP-Induced Mitochondrial Dysfunction and Apoptosis in PC12 Cells. International Journal of Molecular Sciences. 2020; 21(6):2138. https://doi.org/10.3390/ijms21062138

Chicago/Turabian Style

Amara, Ines, Maria Scuto, Agata Zappalà, Maria L. Ontario, Antonio Petralia, Salwa Abid-Essefi, Luigi Maiolino, Anna Signorile, Angela Trovato Salinaro, and Vittorio Calabrese. 2020. "Hericium Erinaceus Prevents DEHP-Induced Mitochondrial Dysfunction and Apoptosis in PC12 Cells" International Journal of Molecular Sciences 21, no. 6: 2138. https://doi.org/10.3390/ijms21062138

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