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Phytochemicals against TNFα-Mediated Neuroinflammatory Diseases

College of Pharmacy, Gachon University, #191, Hambakmoero, Yeonsu-gu, Incheon 21936, Korea
Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi-75270, Pakistan
College of Medicine and Department of Health Science and Technology, GAIHST, Gachon University #155, Gaebeol-ro, Yeonsu-gu, Incheon 21999, Korea
Authors to whom correspondence should be addressed.
These authors contributed equally to this study.
Int. J. Mol. Sci. 2020, 21(3), 764;
Received: 5 December 2019 / Revised: 20 January 2020 / Accepted: 21 January 2020 / Published: 24 January 2020
(This article belongs to the Special Issue Natural Anti-inflammatory Agents 2019)
Tumor necrosis factor-alpha (TNF-α) is a well-known pro-inflammatory cytokine responsible for the modulation of the immune system. TNF-α plays a critical role in almost every type of inflammatory disorder, including central nervous system (CNS) diseases. Although TNF-α is a well-studied component of inflammatory responses, its functioning in diverse cell types is still unclear. TNF-α functions through its two main receptors: tumor necrosis factor receptor 1 and 2 (TNFR1, TNFR2), also known as p55 and p75, respectively. Normally, the functions of soluble TNF-α-induced TNFR1 activation are reported to be pro-inflammatory and apoptotic. While TNF-α mediated TNFR2 activation has a dual role. Several synthetic drugs used as inhibitors of TNF-α for diverse inflammatory diseases possess serious adverse effects, which make patients and researchers turn their focus toward natural medicines, phytochemicals in particular. Phytochemicals targeting TNF-α can significantly improve disease conditions involving TNF-α with fewer side effects. Here, we reviewed known TNF-α inhibitors, as well as lately studied phytochemicals, with a role in inhibiting TNF-α itself, and TNF-α-mediated signaling in inflammatory diseases focusing mainly on CNS disorders. View Full-Text
Keywords: TNF-α; TNFR1; TNFR2; neuroinflammation; neurodegeneration; phytochemicals TNF-α; TNFR1; TNFR2; neuroinflammation; neurodegeneration; phytochemicals
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MDPI and ACS Style

Subedi, L.; Lee, S.E.; Madiha, S.; Gaire, B.P.; Jin, M.; Yumnam, S.; Kim, S.Y. Phytochemicals against TNFα-Mediated Neuroinflammatory Diseases. Int. J. Mol. Sci. 2020, 21, 764.

AMA Style

Subedi L, Lee SE, Madiha S, Gaire BP, Jin M, Yumnam S, Kim SY. Phytochemicals against TNFα-Mediated Neuroinflammatory Diseases. International Journal of Molecular Sciences. 2020; 21(3):764.

Chicago/Turabian Style

Subedi, Lalita, Si E. Lee, Syeda Madiha, Bhakta P. Gaire, Mirim Jin, Silvia Yumnam, and Sun Y. Kim 2020. "Phytochemicals against TNFα-Mediated Neuroinflammatory Diseases" International Journal of Molecular Sciences 21, no. 3: 764.

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