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Volume 21
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10.3390/ijms21030747
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The Endocannabinoid System: A Target for Cancer Treatment

by
Chiara Laezza
1,*,
Cristina Pagano
2,
Giovanna Navarra
2,
Olga Pastorino
2,
Maria Chiara Proto
3,
Donatella Fiore
3,
Chiara Piscopo
3,
Patrizia Gazzerro
3 and
Maurizio Bifulco
2,*
1
Institute of Endocrinology and Experimental Oncology, IEOS CNR, 80131 Naples, Italy
2
Department of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, 80131 Naples, Italy
3
Department of Pharmacy, University of Salerno, 84084 Fisciano (SA), Italy
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(3), 747; https://doi.org/10.3390/ijms21030747
Received: 14 December 2019 / Revised: 17 January 2020 / Accepted: 20 January 2020 / Published: 23 January 2020
(This article belongs to the Special Issue Endocannabinoid System in Health and Disease: Current Situation and Future Perspectives)
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Abstract

In recent years, the endocannabinoid system has received great interest as a potential therapeutic target in numerous pathological conditions. Cannabinoids have shown an anticancer potential by modulating several pathways involved in cell growth, differentiation, migration, and angiogenesis. However, the therapeutic efficacy of cannabinoids is limited to the treatment of chemotherapy-induced symptoms or cancer pain, but their use as anticancer drugs in chemotherapeutic protocols requires further investigation. In this paper, we reviewed the role of cannabinoids in the modulation of signaling mechanisms implicated in tumor progression. View Full-Text
Keywords: Cannabinoids; metastasis; cancer stem cell; angiogenesis Cannabinoids; metastasis; cancer stem cell; angiogenesis
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MDPI and ACS Style

Laezza, C.; Pagano, C.; Navarra, G.; Pastorino, O.; Proto, M.C.; Fiore, D.; Piscopo, C.; Gazzerro, P.; Bifulco, M. The Endocannabinoid System: A Target for Cancer Treatment. Int. J. Mol. Sci. 2020, 21, 747. https://doi.org/10.3390/ijms21030747

AMA Style

Laezza C, Pagano C, Navarra G, Pastorino O, Proto MC, Fiore D, Piscopo C, Gazzerro P, Bifulco M. The Endocannabinoid System: A Target for Cancer Treatment. International Journal of Molecular Sciences. 2020; 21(3):747. https://doi.org/10.3390/ijms21030747

Chicago/Turabian Style

Laezza, Chiara; Pagano, Cristina; Navarra, Giovanna; Pastorino, Olga; Proto, Maria C.; Fiore, Donatella; Piscopo, Chiara; Gazzerro, Patrizia; Bifulco, Maurizio. 2020. "The Endocannabinoid System: A Target for Cancer Treatment" Int. J. Mol. Sci. 21, no. 3: 747. https://doi.org/10.3390/ijms21030747

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