The Endocannabinoid System: A Target for Cancer Treatment
by
Chiara Laezza 1,*, Cristina Pagano 2, Giovanna Navarra 2, Olga Pastorino 2, Maria Chiara Proto 3
, Donatella Fiore 3, Chiara Piscopo 3, Patrizia Gazzerro 3 and Maurizio Bifulco 2,*
Chiara Laezza 1,*, Cristina Pagano 2, Giovanna Navarra 2, Olga Pastorino 2, Maria Chiara Proto 3, Donatella Fiore 3, Chiara Piscopo 3, Patrizia Gazzerro 3 and Maurizio Bifulco 2,*
1
Institute of Endocrinology and Experimental Oncology, IEOS CNR, 80131 Naples, Italy
2
Department of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, 80131 Naples, Italy
3
Department of Pharmacy, University of Salerno, 84084 Fisciano (SA), Italy
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(3), 747; https://doi.org/10.3390/ijms21030747
Received: 14 December 2019 / Revised: 17 January 2020 / Accepted: 20 January 2020 / Published: 23 January 2020
(This article belongs to the Special Issue Endocannabinoid System in Health and Disease: Current Situation and Future Perspectives)
In recent years, the endocannabinoid system has received great interest as a potential therapeutic target in numerous pathological conditions. Cannabinoids have shown an anticancer potential by modulating several pathways involved in cell growth, differentiation, migration, and angiogenesis. However, the therapeutic efficacy of cannabinoids is limited to the treatment of chemotherapy-induced symptoms or cancer pain, but their use as anticancer drugs in chemotherapeutic protocols requires further investigation. In this paper, we reviewed the role of cannabinoids in the modulation of signaling mechanisms implicated in tumor progression.
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Keywords:
Cannabinoids; metastasis; cancer stem cell; angiogenesis
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MDPI and ACS Style
Laezza, C.; Pagano, C.; Navarra, G.; Pastorino, O.; Proto, M.C.; Fiore, D.; Piscopo, C.; Gazzerro, P.; Bifulco, M. The Endocannabinoid System: A Target for Cancer Treatment. Int. J. Mol. Sci. 2020, 21, 747.
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