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Autophagy and Autophagy-Related Diseases: A Review

1
Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo 060-8543, Japan
2
Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo 160-0023, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(23), 8974; https://doi.org/10.3390/ijms21238974
Received: 28 September 2020 / Revised: 19 November 2020 / Accepted: 24 November 2020 / Published: 26 November 2020
(This article belongs to the Special Issue Autophagy in Health, Ageing and Disease 2.0)
Autophagy refers to the process involving the decomposition of intracellular components via lysosomes. Autophagy plays an important role in maintaining and regulating cell homeostasis by degrading intracellular components and providing degradation products to cells. In vivo, autophagy has been shown to be involved in the starvation response, intracellular quality control, early development, and cell differentiation. Recent studies have revealed that autophagy dysfunction is implicated in neurodegenerative diseases and tumorigenesis. In addition to the discovery of certain disease-causing autophagy-related mutations and elucidation of the pathogenesis of conditions resulting from the abnormal degradation of selective autophagy substrates, the activation of autophagy is essential for prolonging life and suppressing aging. This article provides a comprehensive review of the role of autophagy in health, physiological function, and autophagy-related disease. View Full-Text
Keywords: autophagy; autophagy-related gene; mitophagy; cancer; neurodegenerative disease; cardiovascular; liver disease autophagy; autophagy-related gene; mitophagy; cancer; neurodegenerative disease; cardiovascular; liver disease
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MDPI and ACS Style

Ichimiya, T.; Yamakawa, T.; Hirano, T.; Yokoyama, Y.; Hayashi, Y.; Hirayama, D.; Wagatsuma, K.; Itoi, T.; Nakase, H. Autophagy and Autophagy-Related Diseases: A Review. Int. J. Mol. Sci. 2020, 21, 8974. https://doi.org/10.3390/ijms21238974

AMA Style

Ichimiya T, Yamakawa T, Hirano T, Yokoyama Y, Hayashi Y, Hirayama D, Wagatsuma K, Itoi T, Nakase H. Autophagy and Autophagy-Related Diseases: A Review. International Journal of Molecular Sciences. 2020; 21(23):8974. https://doi.org/10.3390/ijms21238974

Chicago/Turabian Style

Ichimiya, Tadashi, Tsukasa Yamakawa, Takehiro Hirano, Yoshihiro Yokoyama, Yuki Hayashi, Daisuke Hirayama, Kohei Wagatsuma, Takao Itoi, and Hiroshi Nakase. 2020. "Autophagy and Autophagy-Related Diseases: A Review" International Journal of Molecular Sciences 21, no. 23: 8974. https://doi.org/10.3390/ijms21238974

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