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DNA Damage Response and Immune Defense

Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156 Milan, Italy
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Int. J. Mol. Sci. 2020, 21(20), 7504; https://doi.org/10.3390/ijms21207504
Received: 23 September 2020 / Revised: 8 October 2020 / Accepted: 10 October 2020 / Published: 12 October 2020
(This article belongs to the Special Issue DNA Repair in Human Disease)
DNA damage is the cause of numerous human pathologies including cancer, premature aging, and chronic inflammatory conditions. The DNA damage response (DDR), in turn, coordinates DNA damage checkpoint activation and promotes the removal of DNA lesions. In recent years, several studies have shown how the DDR and the immune system are tightly connected, revealing an important crosstalk between the two of them. This interesting interplay has opened up new perspectives in clinical studies for immunological diseases as well as for cancer treatment. In this review, we provide an overview, from cellular to molecular pathways, on how DDR and the immune system communicate and share the crucial commitment of maintaining the genomic fitness. View Full-Text
Keywords: DNA damage response; DNA repair; immune defense; immune signalling; innate immunity; cancer DNA damage response; DNA repair; immune defense; immune signalling; innate immunity; cancer
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Nastasi, C.; Mannarino, L.; D’Incalci, M. DNA Damage Response and Immune Defense. Int. J. Mol. Sci. 2020, 21, 7504.

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