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Inactivity and Skeletal Muscle Metabolism: A Vicious Cycle in Old Age

1
Department of Rheumatology and Physiotherapy, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iaşi, Romania
2
Department of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iaşi, Romania
3
Center for Rheumatic Diseases, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania
4
Department of Rheumatology and Physiotherapy,“George Emil Palade” University of Medicine, Pharmacy, Science and Technology, 540139 Târgu Mureş, Romania
5
Department of Pharmacology, Clinical Pharmacology and Algesiology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iaşi, Romania
6
Advanced Center for Research and Development in Experimental Medicine (CEMEX), “Grigore T. Popa” University of Medicine and Pharmacy, 700454 Iaşi, Romania
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(2), 592; https://doi.org/10.3390/ijms21020592 (registering DOI)
Received: 27 November 2019 / Revised: 19 December 2019 / Accepted: 7 January 2020 / Published: 16 January 2020
Aging is an inevitable and gradually progressive process affecting all organs and systems. The musculoskeletal system makes no exception, elderly exhibit an increased risk of sarcopenia (low muscle mass),dynapenia (declining muscle strength), and subsequent disability. Whereas in recent years the subject of skeletal muscle metabolic decline in the elderly has been gathering interest amongst researchers, as well as medical professionals, there are many challenges yet to be solved in order to counteract the effects of aging on muscle function efficiently. Noteworthy, it has been shown that aging individuals exhibit a decline in skeletal muscle metabolism, a phenomenon which may be linked to a number of predisposing (risk) factors such as telomere attrition, epigenetic changes, mitochondrial dysfunction, sedentary behavior (leading to body composition alterations), age-related low-grade systemic inflammation (inflammaging), hormonal imbalance, as well as a hypoproteic diet (unable to counterbalance the repercussions of the age-related increase in skeletal muscle catabolism). The present review aims to discuss the relationship between old age and muscle wasting in an effort to highlight the modifications in skeletal muscle metabolism associated with aging and physical activity. View Full-Text
Keywords: aging; sarcopenia; muscle mitochondria; catabolism; anabolism; inflammation; adipokine; myokine; sedentary lifestyle; exercise aging; sarcopenia; muscle mitochondria; catabolism; anabolism; inflammation; adipokine; myokine; sedentary lifestyle; exercise
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MDPI and ACS Style

Rezuş, E.; Burlui, A.; Cardoneanu, A.; Rezuş, C.; Codreanu, C.; Pârvu, M.; Rusu Zota, G.; Tamba, B.I. Inactivity and Skeletal Muscle Metabolism: A Vicious Cycle in Old Age. Int. J. Mol. Sci. 2020, 21, 592.

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