Next Article in Journal
Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases
Previous Article in Journal
Combined Metabolome and Transcriptome Analyses Reveal the Effects of Mycorrhizal Fungus Ceratobasidium sp. AR2 on the Flavonoid Accumulation in Anoectochilus roxburghii during Different Growth Stages
Open AccessReview

Potential Therapeutic Strategies for Lung and Breast Cancers through Understanding the Anti-Angiogenesis Resistance Mechanisms

by Wafaa S. Ramadan 1,2,†, Dana M. Zaher 1,2,†, Alaa M. Altaie 1,2, Iman M. Talaat 1,3,*,‡ and Adel Elmoselhi 1,4,‡
1
College of Medicine, University of Sharjah, Sharjah 27272, UAE
2
Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, UAE
3
Pathology Department, Faculty of Medicine, Alexandria University, 21526 Alexandria, Egypt
4
Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Equal senior authorship.
Int. J. Mol. Sci. 2020, 21(2), 565; https://doi.org/10.3390/ijms21020565
Received: 7 November 2019 / Revised: 16 December 2019 / Accepted: 3 January 2020 / Published: 15 January 2020
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Breast and lung cancers are among the top cancer types in terms of incidence and mortality burden worldwide. One of the challenges in the treatment of breast and lung cancers is their resistance to administered drugs, as observed with angiogenesis inhibitors. Based on clinical and pre-clinical findings, these two types of cancers have gained the ability to resist angiogenesis inhibitors through several mechanisms that rely on cellular and extracellular factors. This resistance is mediated through angiogenesis-independent vascularization, and it is related to cancer cells and their microenvironment. The mechanisms that cancer cells utilize include metabolic symbiosis and invasion, and they also take advantage of neighboring cells like macrophages, endothelial cells, myeloid and adipose cells. Overcoming resistance is of great interest, and researchers are investigating possible strategies to enhance sensitivity towards angiogenesis inhibitors. These strategies involved targeting multiple players in angiogenesis, epigenetics, hypoxia, cellular metabolism and the immune system. This review aims to discuss the mechanisms of resistance to angiogenesis inhibitors and to highlight recently developed approaches to overcome this resistance. View Full-Text
Keywords: angiogenesis; resistance; angiogenesis inhibitors; breast cancer; lung cancer angiogenesis; resistance; angiogenesis inhibitors; breast cancer; lung cancer
Show Figures

Graphical abstract

MDPI and ACS Style

Ramadan, W.S.; Zaher, D.M.; Altaie, A.M.; Talaat, I.M.; Elmoselhi, A. Potential Therapeutic Strategies for Lung and Breast Cancers through Understanding the Anti-Angiogenesis Resistance Mechanisms. Int. J. Mol. Sci. 2020, 21, 565.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop