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Challenges in Using Circulating Micro-RNAs as Biomarkers for Cardiovascular Diseases

Department of Life and Health Sciences, University of Nicosia, 2417 Nicosia, Cyprus
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(2), 561; https://doi.org/10.3390/ijms21020561 (registering DOI)
Received: 12 December 2019 / Revised: 7 January 2020 / Accepted: 9 January 2020 / Published: 15 January 2020
(This article belongs to the Special Issue RNAs in Cardiovascular Diseases-CardioRNA EU COST Action)
Micro-RNAs (miRNAs) play a pivotal role in the development and physiology of the cardiovascular system while they have been associated with multiple cardiovascular diseases (CVDs). Several cardiac miRNAs are detectable in circulation (circulating miRNAs; c-miRNAs) and are emerging as diagnostic and therapeutic biomarkers for CVDs. c-miRNAs exhibit numerous essential characteristics of biomarkers while they are extremely stable in circulation, their expression is tissue-/disease-specific, and they can be easily detected using sequence-specific amplification methods. These features of c-miRNAs are helpful in the development of non-invasive assays to monitor the progress of CVDs. Despite significant progress in the detection of c-miRNAs in serum and plasma, there are many contradictory publications on the alterations of cardiac c-miRNAs concentration in circulation. The aim of this review is to examine the pre-analytical and analytical factors affecting the quantification of c-miRNAs and provide general guidelines to increase the accuracy of the diagnostic tests in order to improve future research on cardiac c-miRNAs. View Full-Text
Keywords: circulating micro-RNAs; cardiovascular disease; biomarkers; prognosis circulating micro-RNAs; cardiovascular disease; biomarkers; prognosis
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Felekkis, K.; Papaneophytou, C. Challenges in Using Circulating Micro-RNAs as Biomarkers for Cardiovascular Diseases. Int. J. Mol. Sci. 2020, 21, 561.

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