Recent Advancements of Nanomedicine towards Antiangiogenic Therapy in Cancer
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Aavishkar Oral Strips Pvt Ltd., 109/3, IDA, Phase 2, Sector 2, Lane 6, Cherlapally, Hyderabad 500051, India
2
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Jacksonville, FL 32224, USA
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Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, The University of California, Los Angeles (UCLA), Factor Bldg. 10-240, 621 Charles E. Young Dr., Los Angeles, CA 90095, USA
4
Department of Bioengineering, Rice University, Houston, TX 77030, USA
*
Authors to whom correspondence should be addressed.
†
These authors contribute equally to this work.
Int. J. Mol. Sci. 2020, 21(2), 455; https://doi.org/10.3390/ijms21020455
Received: 24 December 2019
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Revised: 7 January 2020
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Accepted: 8 January 2020
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Published: 10 January 2020
(This article belongs to the Special Issue Nanomaterials for Pro-/Anti-Angiogenic Therapies)
Angiogenesis is a process of generation of de-novo blood vessels from already existing vasculature. It has a crucial role in different physiological process including wound healing, embryonic development, and tumor growth. The methods by which therapeutic drugs inhibit tumor angiogenesis are termed as anti-angiogenesis cancer therapy. Developments of angiogenic inhibiting drugs have various limitations causing a barrier for successful treatment of cancer, where angiogenesis plays an important role. In this context, investigators developed novel strategies using nanotechnological approaches that have demonstrated inherent antiangiogenic properties or used for the delivery of antiangiogenic agents in a targeted manner. In this present article, we decisively highlight the recent developments of various nanoparticles (NPs) including liposomes, lipid NPs, protein NPs, polymer NPs, inorganic NPs, viral and bio-inspired NPs for potential application in antiangiogenic cancer therapy. Additionally, the clinical perspectives, challenges of nanomedicine, and future perspectives are briefly analyzed.
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Keywords:
angiogenesis; anti-angiogenesis; nanomedicine; cancer; theranostics
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MDPI and ACS Style
Mukherjee, A.; Madamsetty, V.S.; Paul, M.K.; Mukherjee, S. Recent Advancements of Nanomedicine towards Antiangiogenic Therapy in Cancer. Int. J. Mol. Sci. 2020, 21, 455. https://doi.org/10.3390/ijms21020455
AMA Style
Mukherjee A, Madamsetty VS, Paul MK, Mukherjee S. Recent Advancements of Nanomedicine towards Antiangiogenic Therapy in Cancer. International Journal of Molecular Sciences. 2020; 21(2):455. https://doi.org/10.3390/ijms21020455
Chicago/Turabian StyleMukherjee, Anubhab, Vijay S. Madamsetty, Manash K. Paul, and Sudip Mukherjee. 2020. "Recent Advancements of Nanomedicine towards Antiangiogenic Therapy in Cancer" International Journal of Molecular Sciences 21, no. 2: 455. https://doi.org/10.3390/ijms21020455
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