Oxidative Stress and Microglial Response in Retinitis Pigmentosa
Reviewer 1 Report
The paper is very important from clinical point of view.
Retinitis pigmentosa belongs among hereditary diseases, however, nongenetic factors, maily oxidative stress, contribute to the disease progression.
However, the use of various antioxidants did not provide expected results in animal models or clinical trials.
The authors summarize in their review the current results with the use of various antioxidants with the aim to improve the disease.
The review highly contributes to the elucidation of the role of oxidative stress in retinitis pigmentosa necessary for
the development of a novel antioxidant strategy and therapy.
Reviewer 2 Report
the paper is an interesting review on the effects of ROS in progression of retinitis pigmentosa, there is a lack inconnexion between clinical aspects in human and alterations that it is possible recognize at molecular level, but the paper seems to open a new windov on retinal treatment in several clinical conditions