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Open AccessArticle

Seminal Plasma Analysis of Oxidative Stress in Different Genitourinary Topographical Regions Involved in Reproductive Tract Disorders Associated with Genital Heat Stress

1
Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland
2
Clinic of Urology and Oncological Urology, Poznan University of Medical Sciences, 61-285 Poznan, Poland
3
Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland
4
Department and Clinic Urology and Oncological Urology, Regional Specialist Hospital in Szczecin, 71-455 Szczecin, Poland
5
VitroLive Fertility Clinic in Szczecin, 70-483 Szczecin, Poland
6
Department of Clinical Immunology and Allergology, Danylo Halytskyy Lviv National Medical University, 79008 Lviv, Ukraine
7
Department of Urology, Danylo Halytskyy Lviv National Medical University, 79010 Lviv, Ukraine
8
Department of Paediatric Surgery, Danylo Halytskyy Lviv National Medical University, 79059 Lviv, Ukraine
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(17), 6427; https://doi.org/10.3390/ijms21176427
Received: 3 August 2020 / Revised: 25 August 2020 / Accepted: 26 August 2020 / Published: 3 September 2020
The pathophysiological mechanisms responsible for male subfertility/infertility caused by or complicated by genital heat stress remains unclear in many respects. Because seminal plasma creates the environment for the proper functioning of spermatozoa, in this study, we verified the associations among standard spermiograms, seminal biochemical parameters (neutral alpha-glucosidase, fructose, and citric acid) and oxidative stress markers (total antioxidant capacity, catalase activity, superoxide dismutase activity, and malondialdehyde concentration) in distinct entities associated with male infertility with and without long-time exposure to local hyperthermia. We demonstrated that men exposed to prolonged environmental or clinically recognized local heat stress in adulthood may suffer from dysregulation of seminal antioxidant components, which can be directly associated with epididymal and prostate function. The comparative analysis of the studied parameters showed numerous correlations among all biochemical parameters (particularly neutral alpha-glucosidase) with low standard semen quality in almost all the investigated infertile groups. In light of the data obtained in this originally designed study, we conclude that more attention should be paid to the epididymis and accessory gland function in subfertile and infertile men exposed to genital heat stress, especially in the context of novel treatment algorithms (targeted therapies). View Full-Text
Keywords: genital heat stress; oxidative stress; epididymis; accessory glands genital heat stress; oxidative stress; epididymis; accessory glands
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MDPI and ACS Style

Fraczek, M.; Wojnar, L.; Kamieniczna, M.; Piasecka, M.; Gill, K.; Kups, M.; Chopyak, V.; Havrylyuk, A.; Nakonechnyy, J.; Nakonechnyy, A.; Wozniak, T.; Kurpisz, M. Seminal Plasma Analysis of Oxidative Stress in Different Genitourinary Topographical Regions Involved in Reproductive Tract Disorders Associated with Genital Heat Stress. Int. J. Mol. Sci. 2020, 21, 6427. https://doi.org/10.3390/ijms21176427

AMA Style

Fraczek M, Wojnar L, Kamieniczna M, Piasecka M, Gill K, Kups M, Chopyak V, Havrylyuk A, Nakonechnyy J, Nakonechnyy A, Wozniak T, Kurpisz M. Seminal Plasma Analysis of Oxidative Stress in Different Genitourinary Topographical Regions Involved in Reproductive Tract Disorders Associated with Genital Heat Stress. International Journal of Molecular Sciences. 2020; 21(17):6427. https://doi.org/10.3390/ijms21176427

Chicago/Turabian Style

Fraczek, Monika; Wojnar, Lukasz; Kamieniczna, Marzena; Piasecka, Malgorzata; Gill, Kamil; Kups, Michal; Chopyak, Valentina; Havrylyuk, Anna; Nakonechnyy, Jozef; Nakonechnyy, Andrij; Wozniak, Tomasz; Kurpisz, Maciej. 2020. "Seminal Plasma Analysis of Oxidative Stress in Different Genitourinary Topographical Regions Involved in Reproductive Tract Disorders Associated with Genital Heat Stress" Int. J. Mol. Sci. 21, no. 17: 6427. https://doi.org/10.3390/ijms21176427

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