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The Role of Protein Tyrosine Phosphatases in Inflammasome Activation

Department of Gastroenterology and Hepatology, University Hospital Zurich, 8091 Zurich, Switzerland
Zurich Center for Integrative Human Physiology, University of Zurich, 8006 Zurich, Switzerland
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(15), 5481;
Received: 16 July 2020 / Revised: 29 July 2020 / Accepted: 29 July 2020 / Published: 31 July 2020
(This article belongs to the Special Issue Inflammasome)
Inflammasomes are multi-protein complexes that mediate the activation and secretion of the inflammatory cytokines IL-1β and IL-18. More than half a decade ago, it has been shown that the inflammasome adaptor molecule, ASC requires tyrosine phosphorylation to allow effective inflammasome assembly and sustained IL-1β/IL-18 release. This finding provided evidence that the tyrosine phosphorylation status of inflammasome components affects inflammasome assembly and that inflammasomes are subjected to regulation via kinases and phosphatases. In the subsequent years, it was reported that activation of the inflammasome receptor molecule, NLRP3, is modulated via tyrosine phosphorylation as well, and that NLRP3 de-phosphorylation at specific tyrosine residues was required for inflammasome assembly and sustained IL-1β/IL-18 release. These findings demonstrated the importance of tyrosine phosphorylation as a key modulator of inflammasome activity. Following these initial reports, additional work elucidated that the activity of several inflammasome components is dictated via their phosphorylation status. Particularly, the action of specific tyrosine kinases and phosphatases are of critical importance for the regulation of inflammasome assembly and activity. By summarizing the currently available literature on the interaction of tyrosine phosphatases with inflammasome components we here provide an overview how tyrosine phosphatases affect the activation status of inflammasomes. View Full-Text
Keywords: Tyrosine phosphorylation; PTP; Inflammasome; PTPN22; PTPN2; SHP2; PTP-S2 Tyrosine phosphorylation; PTP; Inflammasome; PTPN22; PTPN2; SHP2; PTP-S2
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Spalinger, M.R.; Schwarzfischer, M.; Scharl, M. The Role of Protein Tyrosine Phosphatases in Inflammasome Activation. Int. J. Mol. Sci. 2020, 21, 5481.

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