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Epigenetic Mechanisms of Inflammasome Regulation

1
Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy
2
Department of Surgical and Biomedical Sciences, Urology and Andrology Clinic, University of Perugia, 05100 Terni, Italy
3
Polo d’Innovazione di Genomica, Genetica e Biologia, 05100 Terni, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(16), 5758; https://doi.org/10.3390/ijms21165758
Received: 1 July 2020 / Revised: 5 August 2020 / Accepted: 8 August 2020 / Published: 11 August 2020
(This article belongs to the Special Issue Inflammasome)
The innate immune system represents the host’s first-line defense against pathogens, dead cells or environmental factors. One of the most important inflammatory pathways is represented by the activation of the NOD-like receptor (NLR) protein family. Some NLRs induce the assembly of large caspase-1-activating complexes called inflammasomes. Different types of inflammasomes have been identified that can respond to distinct bacterial, viral or fungal infections; sterile cell damage or other stressors, such as metabolic imbalances. Epigenetic regulation has been recently suggested to provide a complementary mechanism to control inflammasome activity. This regulation can be exerted through at least three main mechanisms, including CpG DNA methylation, histones post-translational modifications and noncoding RNA expression. The repression or promotion of expression of different inflammasomes (NLRP1, NLRP2, NLRP3, NLRP4, NLRP6, NLRP7, NLRP12 and AIM2) through epigenetic mechanisms determines the development of pathologies with variable severity. For example, our team recently explored the role of microRNAs (miRNAs) targeting and modulating the components of the inflammasome as potential biomarkers in bladder cancer and during therapy. This suggests that the epigenetic control of inflammasome-related genes could represent a potential target for further investigations of molecular mechanisms regulating inflammatory pathways. View Full-Text
Keywords: inflammasome; microRNA; epigenetic modifications inflammasome; microRNA; epigenetic modifications
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MDPI and ACS Style

Poli, G.; Fabi, C.; Bellet, M.M.; Costantini, C.; Nunziangeli, L.; Romani, L.; Brancorsini, S. Epigenetic Mechanisms of Inflammasome Regulation. Int. J. Mol. Sci. 2020, 21, 5758. https://doi.org/10.3390/ijms21165758

AMA Style

Poli G, Fabi C, Bellet MM, Costantini C, Nunziangeli L, Romani L, Brancorsini S. Epigenetic Mechanisms of Inflammasome Regulation. International Journal of Molecular Sciences. 2020; 21(16):5758. https://doi.org/10.3390/ijms21165758

Chicago/Turabian Style

Poli, Giulia; Fabi, Consuelo; Bellet, Marina M.; Costantini, Claudio; Nunziangeli, Luisa; Romani, Luigina; Brancorsini, Stefano. 2020. "Epigenetic Mechanisms of Inflammasome Regulation" Int. J. Mol. Sci. 21, no. 16: 5758. https://doi.org/10.3390/ijms21165758

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