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Open AccessArticle

Benefits of Polydopamine as Particle/Matrix Interface in Polylactide/PD-BaSO4 Scaffolds

1
Department of Mining-Metallurgy Engineering and Materials Science, School of Engineering EIB 1, University of the Basque Country (UPV/EHU) and Polymat, 48013 Bilbao, Spain
2
Center for Research in Medical Devices (CÚRAM), National University of Ireland (NUIG), Newcastle Road, H91 W2TY Galway, Ireland
3
Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Avenida Prof. Gama Pinto, 1649-003 Lisboa, Portugal
4
Laboratory for Bone Metabolism and Regeneration, Faculty of Dental Medicine, U. Porto Rua Dr. Manuel Pereira da Silva, 4200-393 Porto, Portugal
5
Portugal/LAQV/REQUIMTE, U. Porto, 4160-007 Porto, Portugal
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(15), 5480; https://doi.org/10.3390/ijms21155480
Received: 30 June 2020 / Revised: 28 July 2020 / Accepted: 28 July 2020 / Published: 31 July 2020
(This article belongs to the Special Issue Polymeric Scaffolds: Design, Processing, and Biomedical Application)
This work reports the versatility of polydopamine (PD) when applied as a particle coating in a composite of polylactide (PLA). Polydopamine was observed to increase the particle–matrix interface strength and facilitate the adsorption of drugs to the material surface. Here, barium sulfate radiopaque particles were functionalized with polydopamine and integrated into a polylactide matrix, leading to the formulation of a biodegradable and X-ray opaque material with enhanced mechanical properties. Polydopamine functionalized barium sulfate particles also facilitated the adsorption and release of the antibiotic levofloxacin. Analysis of the antibacterial capacity of these composites and the metabolic activity and proliferation of human dermal fibroblasts in vitro demonstrated that these materials are non-cytotoxic and can be 3D printed to formulate complex biocompatible materials for bone fixation devices. View Full-Text
Keywords: biodegradable; composite; polylactide; barium sulfate; polydopamine; melt processing; template; 3D-printing; scaffolds; antibiotic; levofloxacin biodegradable; composite; polylactide; barium sulfate; polydopamine; melt processing; template; 3D-printing; scaffolds; antibiotic; levofloxacin
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MDPI and ACS Style

Sadaba, N.; Larrañaga, A.; Orpella-Aceret, G.; Bettencourt, A.F.; Martin, V.; Biggs, M.; Ribeiro, I.A.C.; Ugartemendia, J.M.; Sarasua, J.-R.; Zuza, E. Benefits of Polydopamine as Particle/Matrix Interface in Polylactide/PD-BaSO4 Scaffolds. Int. J. Mol. Sci. 2020, 21, 5480.

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