Next Article in Journal
Shoot Tip Cryopreservation of Lamprocapnos spectabilis (L.) Fukuhara Using Different Approaches and Evaluation of Stability on the Molecular, Biochemical, and Plant Architecture Levels
Next Article in Special Issue
Evaluation of Different Adiposity Indices and Association with Metabolic Syndrome Risk in Obese Children: Is there a Winner?
Previous Article in Journal
Drug-Related Cutaneous Adverse Events in Philadelphia Chromosome-Negative Myeloproliferative Neoplasms: A Literature Review
Previous Article in Special Issue
Vitamin D and Cardiovascular Risk: Which Implications in Children?
Open AccessArticle

Fatty Acid Profile and Desaturase Activities in 7–10-Year-Old Children Attending Primary School in Verona South District: Association between Palmitoleic Acid, SCD-16, Indices of Adiposity, and Blood Pressure

1
Department of Medicine, University of Verona, Piazzale LA Scuro 10, 37134 Verona, Italy
2
Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Piazzale LA Scuro 10, 37134 Verona, Italy
3
Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(11), 3899; https://doi.org/10.3390/ijms21113899
Received: 16 April 2020 / Revised: 26 May 2020 / Accepted: 27 May 2020 / Published: 30 May 2020
In previous studies, dietary and circulating fatty acids (FA) and desaturases activity (delta-5 desaturase [D5D], delta-6 desaturase [D6D], and stearoyl-CoA desaturase [SCD-16]) involved in their metabolism were associated with metabolic and cardiovascular disorders. The aim of the study was to assess the association between different FAs and desaturases activity (estimated as product:precursor ratios) with individual cardiovascular risk factors (in particular, anthropometric measurements and blood pressure [BP]) in children. The FA profile was determined on a whole-blood drop in 243 children (age: 8.6 ± 0.72 years) participating in a school-based cross-sectional study. Docosahexaenoic acid (DHA) inversely correlated with indices of adiposity, glucose, and triglycerides. Palmitoleic acid and SCD-16 were directly associated with markers of adiposity and BP, even after adjustment for main confounders. D6D correlated directly with the waist/height ratio. Children with excess weight (>85th percentile; that is overweight plus obese ones) showed higher palmitic acid, palmitoleic acid, and higher SCD-16 activity as compared to normal-weight children. Most of the associations were confirmed in the excess-weight group. Omega-3 FAs, particularly DHA, but not omega-6 FA, showed a potentially beneficial association with metabolic parameters, whereas palmitoleic acid and SCD-16 showed a potentially harmful association with indices of adiposity and BP, especially in obese children. View Full-Text
Keywords: palmitoleic acid; SCD-16; obesity; children; desaturase activity; blood pressure palmitoleic acid; SCD-16; obesity; children; desaturase activity; blood pressure
Show Figures

Figure 1

MDPI and ACS Style

Bonafini, S.; Giontella, A.; Tagetti, A.; Bresadola, I.; Gaudino, R.; Cavarzere, P.; Ramaroli, D.A.; Branz, L.; Marcon, D.; Pietrobelli, A.; Minuz, P.; Antoniazzi, F.; Maffeis, C.; Fava, C. Fatty Acid Profile and Desaturase Activities in 7–10-Year-Old Children Attending Primary School in Verona South District: Association between Palmitoleic Acid, SCD-16, Indices of Adiposity, and Blood Pressure. Int. J. Mol. Sci. 2020, 21, 3899. https://doi.org/10.3390/ijms21113899

AMA Style

Bonafini S, Giontella A, Tagetti A, Bresadola I, Gaudino R, Cavarzere P, Ramaroli DA, Branz L, Marcon D, Pietrobelli A, Minuz P, Antoniazzi F, Maffeis C, Fava C. Fatty Acid Profile and Desaturase Activities in 7–10-Year-Old Children Attending Primary School in Verona South District: Association between Palmitoleic Acid, SCD-16, Indices of Adiposity, and Blood Pressure. International Journal of Molecular Sciences. 2020; 21(11):3899. https://doi.org/10.3390/ijms21113899

Chicago/Turabian Style

Bonafini, Sara; Giontella, Alice; Tagetti, Angela; Bresadola, Irene; Gaudino, Rossella; Cavarzere, Paolo; Ramaroli, Diego A.; Branz, Lorella; Marcon, Denise; Pietrobelli, Angelo; Minuz, Pietro; Antoniazzi, Franco; Maffeis, Claudio; Fava, Cristiano. 2020. "Fatty Acid Profile and Desaturase Activities in 7–10-Year-Old Children Attending Primary School in Verona South District: Association between Palmitoleic Acid, SCD-16, Indices of Adiposity, and Blood Pressure" Int. J. Mol. Sci. 21, no. 11: 3899. https://doi.org/10.3390/ijms21113899

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop