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Vitamin D and Cardiovascular Risk: Which Implications in Children?

1
SCDU of Pediatrics, Azienda Ospedaliero-Universitaria Maggiore della Carità, University of Piemonte Orientale, 28100 Novara, Italy
2
Department of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(10), 3536; https://doi.org/10.3390/ijms21103536
Received: 29 April 2020 / Revised: 12 May 2020 / Accepted: 14 May 2020 / Published: 16 May 2020
Vitamin D (25OHD) pleiotropic effects are widely recognized and studied. Recently, vitamin D cardiovascular effects are gaining interest, especially in children, although the studies present conflicting data. Some randomized controlled trials (RCTs) have demonstrated that cardiovascular risk markers, such as lipid parameters, inflammation markers, blood pressure, and arterial stiffness, are unaffected by vitamin D supplementation. By contrast, other studies show that low vitamin D levels are associated with higher risk of cardiovascular disease (CVD) and mortality, and support that increased risk of these diseases occurs primarily in people with vitamin D deficiency. An update on these points in pediatric patients is certainly of interest to focus on possible benefits of its supplementation. View Full-Text
Keywords: childhood; vitamin D; cardiovascular risk; extra-skeletal effects childhood; vitamin D; cardiovascular risk; extra-skeletal effects
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MDPI and ACS Style

Savastio, S.; Pozzi, E.; Tagliaferri, F.; Degrandi, R.; Cinquatti, R.; Rabbone, I.; Bona, G. Vitamin D and Cardiovascular Risk: Which Implications in Children? Int. J. Mol. Sci. 2020, 21, 3536. https://doi.org/10.3390/ijms21103536

AMA Style

Savastio S, Pozzi E, Tagliaferri F, Degrandi R, Cinquatti R, Rabbone I, Bona G. Vitamin D and Cardiovascular Risk: Which Implications in Children? International Journal of Molecular Sciences. 2020; 21(10):3536. https://doi.org/10.3390/ijms21103536

Chicago/Turabian Style

Savastio, Silvia; Pozzi, Erica; Tagliaferri, Francesco; Degrandi, Roberta; Cinquatti, Roberta; Rabbone, Ivana; Bona, Gianni. 2020. "Vitamin D and Cardiovascular Risk: Which Implications in Children?" Int. J. Mol. Sci. 21, no. 10: 3536. https://doi.org/10.3390/ijms21103536

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