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Immunoregulatory Property of C-Type Lectin-Like Receptors in Fibrosing Interstitial Lung Diseases

1
Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
2
Department of Pulmonology and Respiratory Medicine, Medical Faculty of Airlangga University, Surabaya 60131, Indonesia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(10), 3665; https://doi.org/10.3390/ijms21103665
Received: 4 May 2020 / Revised: 20 May 2020 / Accepted: 21 May 2020 / Published: 22 May 2020
(This article belongs to the Special Issue Immunoregulatory Receptor Signaling Networks)
The innate immune system identifies exogenous threats or endogenous stress through germline-encoded receptors called pattern recognition receptors (PRRs) that initiate consecutive downstream signaling pathways to control immune responses. However, the contribution of the immune system and inflammation to fibrosing interstitial lung diseases (ILD) remains poorly understood. Immunoreceptor tyrosine-based motif-bearing C-type lectin-like receptors (CTLRs) may interact with various immune cells during tissue injury and wound repair processes. Dectin-1 is a CTLR with dominant mechanisms manifested through its intracellular signaling cascades, which regulate fibrosis-promoting properties through gene transcription and cytokine activation. Additionally, immune impairment in ILD facilitates microbiome colonization; hence, Dectin-1 is the master protector in host pulmonary defense against fungal invasion. Recent progress in determining the signaling pathways that control the balance of fibrosis has implicated immunoreceptor tyrosine-based motif-bearing CTLRs as being involved, either directly or indirectly, in the pathogenesis of fibrosing ILD. View Full-Text
Keywords: innate immunity; pattern recognition receptors; C-type lectin-like receptors; immunoregulatory receptor; tyrosine-based signaling motifs; interstitial lung diseases innate immunity; pattern recognition receptors; C-type lectin-like receptors; immunoregulatory receptor; tyrosine-based signaling motifs; interstitial lung diseases
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Effendi, W.I.; Nagano, T.; Hasan, H.; Yudhawati, R. Immunoregulatory Property of C-Type Lectin-Like Receptors in Fibrosing Interstitial Lung Diseases. Int. J. Mol. Sci. 2020, 21, 3665.

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