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Article

Delayed NK Cell Reconstitution and Reduced NK Activity Increased the Risks of CMV Disease in Allogeneic-Hematopoietic Stem Cell Transplantation

1
Department of Biomedicine & Health Sciences, Graduate School, The Catholic University of Korea, Seoul 06591, Korea
2
Department of Laboratory Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
3
Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
4
Department of Laboratory Medicine, Catholic Kwandong University International St. Mary’s Hospital, Incheon 22711, Korea
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(10), 3663; https://doi.org/10.3390/ijms21103663
Received: 15 April 2020 / Revised: 18 May 2020 / Accepted: 20 May 2020 / Published: 22 May 2020
(This article belongs to the Special Issue Immunological Investigations in Hematology)
Cytomegalovirus (CMV) infection has a significant impact in patients after allogeneic hematopoietic stem cell transplantation (HSCT). We investigated natural killer (NK) cell reconstitution and cytotoxic/cytokine production in controlling CMV infection, especially severe CMV disease in HSCT patients. Fifty-eight patients with acute myeloid leukemia (AML) who received allo-HSCT were included. We monitored NK reconstitution and NK function at baseline, 30, 60, 90, 120, 150, and 180 days after HSCT, and compared the results in recipients stratified on post-HSCT CMV reactivation (n = 23), non-reactivation (n = 24) versus CMV disease (n = 11) groups. The CMV disease group had a significantly delayed recovery of CD56dim NK cells and expansion of FcRγ-CD3ζ+NK cells started post-HSCT 150 days. Sequential results of NK cytotoxicity, NK cell-mediated antibody-dependent cellular cytotoxicity (NK-ADCC), and NK-Interferon-gamma (NK-IFNγ) production for 180 days demonstrated delayed recovery and decreased levels in the CMV disease group compared with the other groups. The results within 1 month after CMV viremia also showed a significant decrease in NK function in the CMV disease group compared to the CMV reactivation group. It suggests that NK cells’ maturation and cytotoxic/IFNγ production contributes to CMV protection, thereby revealing the NK phenotype and functional NK monitoring as a biomarker for CMV risk prediction, especially CMV disease. View Full-Text
Keywords: cytomegalovirus; hematopoietic stem cell transplantation; acute myeloid leukemia; NK cells; NK cell-mediated antibody-dependent cellular cytotoxicity; NK subsets; IFNγ cytomegalovirus; hematopoietic stem cell transplantation; acute myeloid leukemia; NK cells; NK cell-mediated antibody-dependent cellular cytotoxicity; NK subsets; IFNγ
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MDPI and ACS Style

Park, K.H.; Ryu, J.H.; Bae, H.; Yun, S.; Jang, J.H.; Han, K.; Cho, B.S.; Kim, H.-J.; Lee, H.; Oh, E.-J. Delayed NK Cell Reconstitution and Reduced NK Activity Increased the Risks of CMV Disease in Allogeneic-Hematopoietic Stem Cell Transplantation. Int. J. Mol. Sci. 2020, 21, 3663. https://doi.org/10.3390/ijms21103663

AMA Style

Park KH, Ryu JH, Bae H, Yun S, Jang JH, Han K, Cho BS, Kim H-J, Lee H, Oh E-J. Delayed NK Cell Reconstitution and Reduced NK Activity Increased the Risks of CMV Disease in Allogeneic-Hematopoietic Stem Cell Transplantation. International Journal of Molecular Sciences. 2020; 21(10):3663. https://doi.org/10.3390/ijms21103663

Chicago/Turabian Style

Park, Ki H., Ji H. Ryu, Hyunjoo Bae, Sojeong Yun, Joo H. Jang, Kyungja Han, Byung S. Cho, Hee-Je Kim, Hyeyoung Lee, and Eun-Jee Oh. 2020. "Delayed NK Cell Reconstitution and Reduced NK Activity Increased the Risks of CMV Disease in Allogeneic-Hematopoietic Stem Cell Transplantation" International Journal of Molecular Sciences 21, no. 10: 3663. https://doi.org/10.3390/ijms21103663

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