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Breast Cancer Derived Extracellular Vesicles in Bone Metastasis Induction and Their Clinical Implications as Biomarkers

1
Institute for Biomedical Research and Innovation, National Research Council of Italy, 90146 Palermo, Italy
2
Department of Life, Health and Environmental Sciences, University of L’Aquila, Via Vetoio-Coppito 2, 67100 L’Aquila, Italy
3
Breast Surgery Division, San Salvatore Hospital, 67100 L’Aquila, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Int. J. Mol. Sci. 2020, 21(10), 3573; https://doi.org/10.3390/ijms21103573
Received: 27 April 2020 / Revised: 12 May 2020 / Accepted: 13 May 2020 / Published: 18 May 2020
(This article belongs to the Special Issue Extracellular Vesicles and Metastatic Niche 2.0)
Cancer incidence and mortality are rapidly growing worldwide. The main risk factors for cancer can be associated with aging as well as the growth of the population and socioeconomic condition. Breast cancer, a crucial public health problem, is the second cause of death among women. About 70% of patients with advanced breast cancer have bone metastases. In bone metastasis, cancer cells and osteoclasts form a vicious cycle: cancer cells promote osteoclast differentiation and activation that, in turn, induce cancer cell seeding and proliferation in the bone. Growing evidence shows that extracellular vesicles (EVs) play a key role in carcinogenesis, proliferation, pre-metastatic niche formation, angiogenesis, metastasis, and chemoresistance in several tumors, such as breast, lung, prostate, and liver cancer. Here, we discuss the role of EVs released by breast cancer cells, focusing on bone metastasis induction and their clinical implications as biomarkers. View Full-Text
Keywords: EVs; extracellular vesicles; breast cancer; metastatic niche; bone metastasis; breast cancer biomarkers; liquid biopsy EVs; extracellular vesicles; breast cancer; metastatic niche; bone metastasis; breast cancer biomarkers; liquid biopsy
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MDPI and ACS Style

Taverna, S.; Giusti, I.; D’Ascenzo, S.; Pizzorno, L.; Dolo, V. Breast Cancer Derived Extracellular Vesicles in Bone Metastasis Induction and Their Clinical Implications as Biomarkers. Int. J. Mol. Sci. 2020, 21, 3573. https://doi.org/10.3390/ijms21103573

AMA Style

Taverna S, Giusti I, D’Ascenzo S, Pizzorno L, Dolo V. Breast Cancer Derived Extracellular Vesicles in Bone Metastasis Induction and Their Clinical Implications as Biomarkers. International Journal of Molecular Sciences. 2020; 21(10):3573. https://doi.org/10.3390/ijms21103573

Chicago/Turabian Style

Taverna, Simona, Ilaria Giusti, Sandra D’Ascenzo, Laura Pizzorno, and Vincenza Dolo. 2020. "Breast Cancer Derived Extracellular Vesicles in Bone Metastasis Induction and Their Clinical Implications as Biomarkers" International Journal of Molecular Sciences 21, no. 10: 3573. https://doi.org/10.3390/ijms21103573

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