Extracellular Vesicles: Messengers of p53 in Tumor–Stroma Communication and Cancer Metastasis
Abstract
:1. The TP53 Tumor Suppressor in Cancer
2. Extracellular Vesicles—Biogenesis, Cargo and Uptake
3. Extracellular Vesicles—Function in Cancer
3.1. EVs Shape a Tumor-Supporting Microenvironment
3.2. EVs Stimulate Metastasis and Prime Metastatic Niches
4. EVs as Extracellular Messengers of p53
4.1. EVs Communicate Tumor Suppressive Signals of Wild-Type p53
4.1.1. p53 Stimulates EV Secretion
4.1.2. p53 Controls EV Size
4.1.3. p53 Promotes EV Loading with Anti-Metastatic Cargo
4.1.4. p53 Suppresses the Generation of Cancer-Associated Fibroblasts through EVs
4.1.5. p53 Supports Chemoimmunotherapy Responses through EVs
4.2. EVs Communicate Tumor-Promoting Signals from Mutant p53
4.2.1. Mutant p53 Effects on EV miRNA Cargo
4.2.2. Mutant p53 Effects on EV Protein Cargo
5. Conclusions
Funding
Conflicts of Interest
References
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Pavlakis, E.; Neumann, M.; Stiewe, T. Extracellular Vesicles: Messengers of p53 in Tumor–Stroma Communication and Cancer Metastasis. Int. J. Mol. Sci. 2020, 21, 9648. https://doi.org/10.3390/ijms21249648
Pavlakis E, Neumann M, Stiewe T. Extracellular Vesicles: Messengers of p53 in Tumor–Stroma Communication and Cancer Metastasis. International Journal of Molecular Sciences. 2020; 21(24):9648. https://doi.org/10.3390/ijms21249648
Chicago/Turabian StylePavlakis, Evangelos, Michelle Neumann, and Thorsten Stiewe. 2020. "Extracellular Vesicles: Messengers of p53 in Tumor–Stroma Communication and Cancer Metastasis" International Journal of Molecular Sciences 21, no. 24: 9648. https://doi.org/10.3390/ijms21249648