Extracellular Vesicles: Messengers of p53 in Tumor–Stroma Communication and Cancer Metastasis
Abstract
1. The TP53 Tumor Suppressor in Cancer
2. Extracellular Vesicles—Biogenesis, Cargo and Uptake
3. Extracellular Vesicles—Function in Cancer
3.1. EVs Shape a Tumor-Supporting Microenvironment
3.2. EVs Stimulate Metastasis and Prime Metastatic Niches
4. EVs as Extracellular Messengers of p53
4.1. EVs Communicate Tumor Suppressive Signals of Wild-Type p53
4.1.1. p53 Stimulates EV Secretion
4.1.2. p53 Controls EV Size
4.1.3. p53 Promotes EV Loading with Anti-Metastatic Cargo
4.1.4. p53 Suppresses the Generation of Cancer-Associated Fibroblasts through EVs
4.1.5. p53 Supports Chemoimmunotherapy Responses through EVs
4.2. EVs Communicate Tumor-Promoting Signals from Mutant p53
4.2.1. Mutant p53 Effects on EV miRNA Cargo
4.2.2. Mutant p53 Effects on EV Protein Cargo
5. Conclusions
Funding
Conflicts of Interest
References
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Pavlakis, E.; Neumann, M.; Stiewe, T. Extracellular Vesicles: Messengers of p53 in Tumor–Stroma Communication and Cancer Metastasis. Int. J. Mol. Sci. 2020, 21, 9648. https://doi.org/10.3390/ijms21249648
Pavlakis E, Neumann M, Stiewe T. Extracellular Vesicles: Messengers of p53 in Tumor–Stroma Communication and Cancer Metastasis. International Journal of Molecular Sciences. 2020; 21(24):9648. https://doi.org/10.3390/ijms21249648
Chicago/Turabian StylePavlakis, Evangelos, Michelle Neumann, and Thorsten Stiewe. 2020. "Extracellular Vesicles: Messengers of p53 in Tumor–Stroma Communication and Cancer Metastasis" International Journal of Molecular Sciences 21, no. 24: 9648. https://doi.org/10.3390/ijms21249648
APA StylePavlakis, E., Neumann, M., & Stiewe, T. (2020). Extracellular Vesicles: Messengers of p53 in Tumor–Stroma Communication and Cancer Metastasis. International Journal of Molecular Sciences, 21(24), 9648. https://doi.org/10.3390/ijms21249648